Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A
Catalytic asymmetric synthesis of the C1-C15 segment of spirastrellolide A
复制标题
螺旋菌内酯A C1-C15 片段的催化不对称合成
DOI：
10.1055/s-0036-1588068
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Masakatsu Shibasaki
中科院分区：
文献类型：
--
作者：
Yui Sahara;Jin Cui;Makoto Furutachi;Jingbo Chen;Takumi Watanabe;Masakatsu Shibasaki
实现了天然存在的 PP2A 抑制剂 spirastrellolide A C1-C15 片段的催化不对称合成。为了以立体定义的方式构建1,3-多元醇系统，我们利用了迭代羟醛策略，包括催化不对称硫代酰胺-羟醛反应和非对映选择性巴豆酰化过程。因此，通过 14 步程序获得了螺旋菌内酯 A 全合成的潜在片段。
Catalytic asymmetric synthesis of the C1–C15 fragment of spirastrellolide A, a naturally occurring PP2A inhibitor, was achieved. To construct the 1,3-polyol system in a stereodefined manner, we took advantage of an iterative aldol strategy comprising the catalytic asymmetric thioamide-aldol reaction, and a diastereoselective crotylation process. A potential segment for the total synthesis of spirastrellolide A was thus accessed through a 14-step procedure.