Decreased maternal protein S activity is associated with fetal growth restriction
Decreased maternal protein S activity is associated with fetal growth restriction
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DOI：
10.1016/j.thromres.2008.01.016
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发表时间：
2008-01-01
影响因子：
7.5
通讯作者：
Wake, Norio
中科院分区：
文献类型：
--
作者：
Hojo, Satoshi;Tsukimori, Kiyomi;Wake, Norio
简介：蛋白S（PS）活性已被证明在正常怀孕期间会降低。本研究的目的是确定任何降低母体PS活性和胎儿生长受限（FGR）之间的相关性。方法：我们进行了一项回顾性研究的母体PS活性和补体4 b结合蛋白（C4 BP）浓度在102例FGR和58例胎儿正常生长。在受FGR影响的妊娠中，有14例在妊娠中期诊断，88例在妊娠晚期诊断。胎儿正常生长的患者与FGR受试者在采样时的母亲年龄和胎龄相匹配（中、晚期各29例）。结果：对照组中晚期的平均PS活性显著低于中晚期（56.5 +/- 16.5% vs 35.8 +/- 13.8%）。与对照组水平相比，FGR女性的PS活性在孕中期（36.6 +/- 13.2%）和孕晚期（30.2 +/- 12.2%）均显著降低。对照组的C4 BP血浆浓度在妊娠晚期显著高于妊娠中期（90.5 +/- 17.5% vs 81.1 +/- 13.6%）。然而，在妇女与FGR，血浆C4 BP浓度在第二个三个月（84.0 +/- 14.8%）和第三个三个月（86.0 +/- 17.7%）与concentrations of the control group.Conclusions：产妇PS活性下降，正常妊娠的进展，但随着时间的推移下降的情况下，FGR。PS活性在怀孕期间过度降低可能有助于FGR的发展。(C)2008爱思唯尔有限公司版权所有
Introduction: Protein S (PS) activity has been shown to decrease during normal pregnancy. The aim of this study was to determine any correlation between decreased maternal PS activity and fetal growth restriction (FGR).Methods: We carried out a retrospective study of maternal PS activity and complement 4b-binding protein (C4BP) concentration in 102 patients with FGR and 58 patients with fetuses that had normal growth. Among pregnancies affected by FGR, 14 diagnoses were made in the second trimester and 88 in the third trimester. Patients whose fetuses had normal growth were matched with FGR subjects for maternal age and gestational age at sampling (29 cases each in the second and third trimester).Results: Mean PS activity of the control group in the third trimester was significantly lower than in the second trimester (56.5 +/- 16.5% vs 35.8 +/- 13.8%). PS activity in women with FGR was significantly decreased in both the second trimester (36.6 +/- 13.2%) and third trimester (30.2 +/- 12.2%) compared with control group levels. Plasma concentrations of C4BP for the control group were significantly higher in the third trimester than in the second trimester (90.5 +/- 17.5% vs 81.1 +/- 13.6%). However, in women with FGR, plasma C4BP concentrations in both the second trimester (84.0 +/- 14.8%) and the third trimester (86.0 +/- 17.7%) were comparable with concentrations of the control group.Conclusions: Maternal PS activity decreased as normal pregnancies progressed but decreased over time in cases with FGR. Excessive decreases in PS activity during pregnancy could contribute to development of FGR. (C) 2008 Elsevier Ltd. All rights reserved