Mechanisms of leukocyte regulation by complement-derived factors.
Mechanisms of leukocyte regulation by complement-derived factors.
复制标题
补体衍生因子调节白细胞的机制。
DOI：
10.1007/978-1-4757-4862-8_4
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Morgan,EL
中科院分区：
文献类型：
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作者：
Hugli,TE;Morgan,EL
早在20世纪60年代中期，人们就认识到来自血液补体系统的因子可以刺激白细胞并促进白细胞的定向迁移(Ward等人，1965,1967；Shin等人，1968；Snyderman等人，1968)。此后不久，有人指定将过敏毒素确定为所讨论的体液趋化因子(Jensen等人，1969；Hill和Ward，1969；Ward 1967,1969；Cochrane和Muller-Eberhard，1968；Fernandez等人，1978)。过敏性毒素是当补体级联被激活时从血清成分C3、C4和C5中释放出来的低分子片段；这些片段分别被命名为C3a、C4a和C5a。最近的几篇综述非常详细地描述了过敏毒素的性质(Hugli和Muller-Eberhard，1978；Hugh，1978,1981,1982)。在过敏性毒素被确定为趋化因子之前，它们主要是因为它们的痉挛和促进通透性的活性，主要是通过肥大细胞释放的血管胺介导的(Johnson等人，1975)。然而，正是对中性粒细胞-过敏性毒素相互作用的认识，将趋化性作为细胞激活的指标，促使人们发现了许多由这些过敏性毒素介导的其他白细胞反应。关于过敏性毒素对白细胞功能的多重影响的知识现状是本章的主题。
As early as the mid· 1960s it was recognized that factors derived from the blood complement system could stimulate leukocytes and promote directed leukocyte migration (Ward et al., 1965, 1967; Shin et al., 1968; Snyderman et al., 1968). Shortly thereafter assignments were made that identified anaphylatoxins as the humoral chemotactic factors in question (Jensen et al., 1969; Hill and Ward, 1969; Ward 1967, 1969; Cochrane and Muller-Eberhard, 1968; Fernandez et al., 1978). Anaphylatoxins are low-molecular-weight fragments released from serum components C3, C4, and C5 when the complement cascade is activated; these fragments have been designated C3a, C4a, and C5a, respectively. Several recent reviews describe the properties of the anaphylatoxins in great detail (Hugli and Muller-Eberhard, 1978; HugH, 1978, 1981, 1982). Before the anaphylatoxins were identified as chemotaxins, they were noted primarily for their spasmogenic and permeability-enhancing activities, mediated largely via vasoamines released from the mast cell (Johnson et al., 1975). However, it was the recognition of neutrophil-anaphylatoxin interactions, using chemotaxis as an indicator of cellular activation, that prompted discovery of numerous other leukocyte responses mediated by these anaphylatoxins. The current status of our knowledge concerning the multiple effects of the anaphylatoxins on leukocyte function is the subject of this chapter.