A SURGICAL MODEL FOR NORMOTENSIVE CHRONIC-RENAL-FAILURE IN THE GROWING PIGLET
A SURGICAL MODEL FOR NORMOTENSIVE CHRONIC-RENAL-FAILURE IN THE GROWING PIGLET
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DOI：
10.1016/s0022-5347(17)36712-5
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发表时间：
1992-08-01
影响因子：
6.6
通讯作者：
CHURCHILL, BM
中科院分区：
文献类型：
--
作者：
MCKENNA, PH;KHOURY, AE;CHURCHILL, BM
由于缺乏合适的血压正常的肾衰竭大型哺乳动物模型，研究慢性尿毒症对儿童的影响一直受到阻碍。我们在22头家猪中使用吻合器和可吸收斯台普斯进行肾切除术，同时进行对侧肾部分切除术。该方法可切除肾肿瘤的93%以上。慢性尿毒症状态可重复发展，并与肾质量切除的百分比相关。吻合器肾部分切除术无相关术后并发症。与轻度肾衰竭猪相比，中度肾衰竭猪的生长显著下降，这代表了血压正常的大型哺乳动物模型的成功开发，该模型可用于研究快速生长状态下慢性肾衰竭和高滤过的影响。此外，本研究证实了吻合器成功用于肾部分切除术。
Studying the effects of chronic uremia in children has been hindered by the lack of a suitable large mammalian animal model with normotensive renal failure. We performed nephrectomy with simultaneous contralateral partial nephrectomy using a stapling device and absorbable staples in 22 domestic piglets. Up to 93% of the total renal mass could be excised by this method. A chronic uremic state was reproducibly developed and correlated with the percentage of renal mass excised. There were no associated postoperative complications with the stapled partial nephrectomy. Pigs with moderate renal failure had a significant decrease in growth compared to those with mild renal failure, which represents the successful development of a normotensive large mammalian animal model that could be used to study the effects of chronic renal failure and hyperfiltration during a state of rapid growth. In addition, this study confirms the successful use of a stapling device to perform partial nephrectomy.