Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease
Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease
复制标题
DOI：
10.1136/thx.51.8.819
复制
发表时间：
1996-08-01
期刊：
影响因子：
10
通讯作者：
Wouters, EFM
中科院分区：
文献类型：
--
作者：
Schols, AMWJ;Buurman, WA;Wouters, EFM
背景-慢性阻塞性肺疾病（COPD）患者通常会出现静息能量消耗（REE）增加，其原因尚不清楚。本研究的目的是评估COPD患者REE、急性期蛋白和炎症介质之间的关系。方法-研究了30例患者，并以26名年龄匹配的健康受试者作为对照。REE通过间接量热法测量，并通过生物电阻抗分析调整无脂肪质量（FFM）。肿瘤坏死因子-α（TNF-α），可溶性肿瘤坏死受体（sTNF-R）55和sTNF-R75，白细胞介素（IL）-6，IL-8和脂多糖结合蛋白（LBP）通过ELISA测定。后者的平均体重指数和脂肪量显着降低，但肺功能数据在两组中相似。在30名COPD患者中，平均（SD）sTNF-R75为1.7（1.0）ng/ml，而对照组为1.1（0.4）ng/ml; 8名患者可检测到C-反应蛋白（CRP）（>5 μ g/ml），而对照组无一例检测到; LBP为13.2（7.7）μ g/ml，而对照组为8.6（3.1）μ g/ml。与REE正常的患者相比，REE升高的患者CRP平均水平升高（中位数为5.5 μ g/ml（范围5-193），
Background - An increase in resting energy expenditure (REE) commonly occurs in patients with chronic obstructive pulmonary disease (COPD), the cause of which is as yet unknown. The objective of this study was to assess the relationship between REE, acute phase proteins, and inflammatory mediators in patients with COPD.Methods - Thirty patients were studied and 26 healthy age-matched subjects served as controls. REE was measured by indirect calorimetry and adjusted for fat-free mass (FFM) by bioelectrical impedance analysis. Tumour necrosis factor alpha (TNF-alpha), soluble tumour necrosis receptor (sTNF-R) 55 and sTNF-R75, interleukin (IL)-6, IL-8, and lipopolysaccharide binding protein (LBP) were measured by ELISA.Results - Fourteen patients had a normal REE and in 16 it was raised. The mean body mass index and fat mass were significantly lower in the latter but pulmonary function data were similar in the two groups. In the 30 patients with COPD the mean (SD) sTNF-R75 was 1.7 (1.0) ng/ml compared with 1.1 (0.4) ng/ml in the controls; C-reactive protein (CRP) was detectable (>5 mu g/ml) in eight patients compared with none of the control subjects, and LBP was 13.2 (7.7) mu g/ml compared with 8.6 (3.1) mu g/ml in the controls. The patients with a raised REE had increased mean levels of CRP compared with the patients with a normal REE (median 5.5 mu g/ml (range 5-193) and