Extracellular heat shock proteins (eHSPs) pilot exogenous antigen into cross-presentation pathway: A superguide from extracellular world to intracellular tour
Extracellular heat shock proteins (eHSPs) pilot exogenous antigen into cross-presentation pathway: A superguide from extracellular world to intracellular tour
复制标题
细胞外热休克蛋白（eHSP）引导外源抗原进入交叉呈递途径：从细胞外世界到细胞内之旅的超级指南
DOI：
10.4993/acrt.15.41
复制
发表时间：
2007
影响因子：
--
通讯作者：
N. Sato
中科院分区：
文献类型：
--
作者：
Y. Tamura;G. Kutomi;J. Oura;T. Torigoe;N. Sato
热休克蛋白(HSPs)是细胞内的伴侣蛋白，当其释放到细胞外环境中时，既可以作为免疫佐剂，也可以作为免疫系统的危险信号。这些热休克蛋白与它们的客户多肽一起，与抗原提呈细胞(APC)上的受体特异性结合。这导致了APC的分化，同时伴随着与T细胞交叉呈递的伴随肽的传递。HSP-APC的相互作用是通过几种受体介导的内吞作用或信号转导发生的。最重要的是，HSP相关抗原被APC强迫进入交叉递呈途径，导致CD8+T细胞活化。我们将讨论热休克蛋白在产生免疫反应方面的这些独特功能。
Heat shock proteins (HSPs) are intracellular chaperone, some of which function as immune adjuvants as well as danger signals for immune system when released into extracellular milieu. These HSPs, along with their client polypeptides, are specifically bound by receptors on antigen presenting cells (APCs). This leads to APC differentiation along with delivery of the chaperoned peptides for cross-presentation to T cells. HSP-APC interactions occur through several receptors that mediate endocytosis or signal transduction. Most importantly, HSP associated antigens are forced to enter the cross-presentation pathway by APCs, resulting in CD8+ T cell activation. These unique features of HSPs for the generation of immune response will be discussed.
登录
查看更多内容
影响因子：
4.4
作者：
H. Udono;P. K. Srivastava
通讯作者：
H. Udono;P. K. Srivastava
影响因子：
32.4
作者：
Basu, S;Binder, RJ;Srivastava, PK
通讯作者：
Srivastava, PK
影响因子：
4.4
作者：
Basu, S;Binder, RJ;Srivastava, PK
通讯作者：
Srivastava, PK
影响因子：
56.9
作者：
SUTO, R;SRIVASTAVA, PK
通讯作者：
SRIVASTAVA, PK