Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
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DOI：
10.1016/s0264-410x(03)00355-4
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发表时间：
2003-07-28
期刊：
影响因子：
5.5
通讯作者：
Glezen, WP
中科院分区：
文献类型：
--
作者：
Piedra, PA;Jewell, AM;Glezen, WP
目的：为了确定呼吸道合胞病毒（RSV）特异性血清抗体滴度是否与所有年龄段的RSV相关住院保护相关。283（2000）499]，如果他们在1991年7月至1993年6月期间入组，进行了病毒分离培养，并在住院时和14-60天后提供了血液样本，则纳入我们的分析。RSV感染由阳性培养和/或血清学确定。结果：538例急性呼吸道感染住院患者中，175例（1个月~ 89岁）符合分析标准。27例1岁以下婴幼儿中11例（40.7%）、21例1 ~ 12岁幼儿中8例（38.1%）发生RSV合并住院。
Objective: To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages.Design: Participants who were enrolled in a trial to determine the frequency of specific virus infections associated with hospitalization [J. Am. Med. Assoc. 283 (2000) 499] were included in our analysis if they were enrolled from July 1991 to June 1993, had a culture for virus isolation, and provided blood samples at hospitalization and 14-60 days later. RSV infection was defined by a positive culture and/or serology. Microneutralization, ELISA to the fusion (F) protein and Western blot were the serological assays that were used to determine correlates of immunity.Results: One hundred and seventy-five individuals, I month to 89 years old, out of 538 patients hospitalized with an acute respiratory infection met the criteria for analysis. RSV as sociated-hospitalization occurred in 11 (40.7%) of 27 infants (< 1 year), 8 (38.1%) of 21 young children (1 to