The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users.
The Effect of Increasing Interphase Gap on N1 Latency of the Electrically Evoked Compound Action Potential and the Stimulation Level Offset in Human Cochlear Implant Users.
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DOI：
10.1097/aud.0000000000000919
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
He S
中科院分区：
文献类型：
--
作者：
Skidmore J;He S
本研究报告了人工耳蜗（CI）使用者耳蜗神经（CN）生理状态的两种潜在生物标志物。该项目代表了对我们最近发表的研究中的电生理数据子集的补充分析。这项研究比较了N1潜伏期和刺激水平的变化（即，N1潜伏期偏移和刺激水平偏移）与耳蜗神经缺陷（CND）儿童和正常大小CN儿童之间的双相脉冲的相间间隙增加。在所有测试的电极位置，与正常大小的CN儿童相比，CND儿童显示出较小的N1潜伏期偏移和较大的刺激水平偏移。CN生理状态不同的两个患者人群的N1潜伏期和刺激水平偏移不同。这些参数可用于评估CN功能在个别CI患者。
This study reports two potential biomarkers of the physiological status of the cochlear nerve (CN) in cochlear implant (CI) users. This project represents a complementary analysis on a subset of electrophysiological data from our recently published study. This study compared changes in N1 latency and stimulation level (i.e., N1 latency offset and stimulation level offset) with increasing interphase gap of a biphasic pulse between children with cochlear nerve deficiency (CND) and children with normal-sized CNs. Children with CND showed smaller N1 latency offsets and larger stimulation level offsets than children with normal-sized CNs at all electrode locations tested. The N1 latency and stimulation level offsets differ in two patient populations with different physiological statuses of the CN. These parameters may be useful for evaluating CN function in individual CI patients.