Structural and functional brain integrity of fetal alcohol syndrome in nonretarded cases
Structural and functional brain integrity of fetal alcohol syndrome in nonretarded cases
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DOI：
10.1542/peds.105.5.1096
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发表时间：
2000-05-01
期刊：
影响因子：
8
通讯作者：
Loock, C
中科院分区：
文献类型：
--
作者：
Clark, CM;Li, D;Loock, C
目的.目的：确定诊断为胎儿酒精综合征的非智力迟钝个体的大脑结构和功能完整性。样本包括19个人谁符合胎儿酒精综合征的诊断标准。智力功能采用韦氏成人智力量表修订版进行评估。使用磁共振成像评估大脑的结构完整性，而使用正电子发射断层扫描和F-18-氟脱氧葡萄糖评估功能完整性。平均全量表IQ为80.2（范围：66 - 92）。仅1例磁共振成像发现异常。这种异常是在智商最低的受试者中发现的。在包括丘脑和基底节在内的5个脑区发现相对局部脑代谢率降低。这些结果与以前的研究结果表明，胎儿酒精综合征的神经病理连续。对于智力缺陷相对较轻的情况，缺陷的原因是在微观层面而不是宏观层面。
Purpose. To determine the structural and functional integrity of the brain in a sample of nonretarded individuals diagnosed with fetal alcohol syndrome.Subjects. The sample consisted of nineteen individuals who met the diagnostic criteria for fetal alcohol syndrome.Methods. Intellectual function was assessed using the Wechsler Adult Intelligence Scale-Revised. Structural integrity of the brain was assessed using magnetic resonance imaging whereas functional integrity was assessed using positron emission tomography and F-18-fluorodeoxyglucose.Results. The mean Full Scale IQ was 80.2 (range: 66-92). Only 1 magnetic resonance imaging was found to be abnormal. This abnormality was found for the subject with the lowest IQ. Decreases in relative regional cerebral metabolic rates were found in 5 brain regions comprising the thalamus and basal ganglia.Conclusion. These results when coupled with previous findings suggest a continuum of neuropathology in fetal alcohol syndrome. For cases with relatively mild intellectual deficits, the cause of the deficit is at a microlevel rather than a macro-level.