Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy.
Neutron-Activatable Nanoparticles for Intraperitoneal Radiation Therapy.
复制标题
用于腹腔放射治疗的中子激活纳米颗粒。
DOI：
10.1007/978-1-4939-6646-2_24
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Lu,Xiuling
中科院分区：
文献类型：
--
作者：
Hargrove,Derek;Lu,Xiuling
腹腔内放射治疗是一种癌症治疗选择，用于手术切除、全身化疗和外照射放射治疗对患者不适用的情况。然而，非癌组织暴露于辐射仍然是安全和有效治疗患者的障碍。此外，在制备内部放射治疗剂期间减少人员的长时间辐射暴露使得它们的制造复杂且危险。纳米技术的发展为靶向治疗提供了一个平台，该平台将联合收割机的双重成像和治疗能力全部结合在一个包装中，同时还足够坚固以承受中子活化期间所面临的强烈应力。在这里，我们描述了一种用于合成可中子活化的介孔二氧化硅纳米颗粒的方法，该纳米颗粒用于转移性腹膜癌的放射治疗，同时限制个人暴露于放射性材料，限制中子活化期间纳米颗粒降解引起的放射性同位素泄漏，并增加放射的癌症组织特异性。
Intraperitoneal internal radiation therapy is a cancer treatment option that is employed in situations where surgical resection, systemic chemotherapy, and external beam radiotherapy are not amenable for patients. However, exposure of noncancerous tissues to radiation continues to be a hindrance to safe and effective treatment of patients. In addition, reducing prolonged radiation exposure of personnel during preparation of internal radiation therapy agents makes their manufacture complicated and hazardous. Developments in nanotechnology have provided a platform for targeted treatments that combine dual imaging and treatment capabilities all in one package, while also being robust enough to withstand the intense stresses faced during neutron activation. Here, we describe a method for synthesizing neutron activatable mesoporous silica nanoparticles for use in radiotherapy of metastatic peritoneal cancers while limiting personal exposure to radioactive materials, limiting the leakage of radioactive isotopes caused by nanoparticle degradation during neutron activation, and increasing cancer tissue specificity of radiation.