Forty-five years' experience of the treatment of choriocarcinoma and invasive mole
Forty-five years' experience of the treatment of choriocarcinoma and invasive mole
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DOI：
10.1016/s0020-7292(98)80009-x
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发表时间：
1998-04-01
影响因子：
3.8
通讯作者：
Xiang, Y
中科院分区：
文献类型：
--
作者：
Song, HZ;Yang, XY;Xiang, Y
我们的工作是从1949年开始的。经过多年的努力，几种化学物质（如6mp， 5fu等）被发现对绒毛膜癌（C.C.）和侵袭性痣（I.M.）有效。从1959年到1985年，1500名患者接受了连续治疗。CC的死亡率由原来的90%降至20%以下。没有更多的死亡发生在IM。所有幸存者随访10-38年未发现残留疾病的证据。单独化疗的年轻患者中有80%在康复后怀孕。妊娠结局与一般人群无明显差异。非盟儿童正常成长，许多人结婚并生育了正常的第三代。结果表明，5fu化疗不仅可以完全缓解，而且可以治愈，即使有广泛的转移。本文报道了以5fu为主治疗绒毛膜癌和侵袭性痣的结果。总结了不同部位转移治疗的临床经验。
Our work was begun in 1949. through many yera's effort, several chemicals (such as 6 MP, 5 FU and others) were found to be effective for the treatment of choriocarcinoma (C.C.) and invasive mole (I.M.). From 1959 through 1985, 1500 patients were consecutively treated. The mortality rate of CC was reduced from > 90% to < 20%. No more death occurred in IM. All Survivors followed up for 10-38 years showed no evidence of residual disease. 80% of the young patients treated with chemotherapy alone conceived after recovery. The pregnancy outcome showed no deviation from that of the general population. AU children are growing up normally many married and gave birth to normal third generations. The results indicated that chemotherapy with 5 FU achieves not only a complete remission, but also a cure, even with wide-spread metastases. The results of choriocarinoma and invasive mole treated with mainly 5 FU were reported. The clinical experience in the management of metastases at different sites were also summarized.