Nonalcoholic fatty liver disease associated with impairment of kidney function in nondiabetes population.
Nonalcoholic fatty liver disease associated with impairment of kidney function in nondiabetes population.
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非糖尿病人群中非酒精性脂肪肝与肾功能损害相关
DOI：
10.11613/bm.2012.010
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发表时间：
2012
期刊：
影响因子：
3.3
通讯作者：
Yin D
中科院分区：
文献类型：
--
作者：
Li G;Shi W;Hug H;Chen Y;Liu L;Yin D
背景：非酒精性脂肪性肝病（NAFLD）与肾脏负担增加有关。然而，在校正混杂因素后，目前仍没有大型人群研究来探讨NAFLD与轻度肾功能损害（MKFD）之间的潜在关系。本研究在控制混杂因素的影响下，检验NAFLD与MKFD相关的假设。材料与方法：分析1412例中国汉族成人空腹血糖、肌酐、胆固醇、甘油三酯、丙氨酸转氨酶和天冬氨酸转氨酶水平。通过问卷调查和体格检查来探讨NAFLD与肾功能的潜在关联。结果：NAFLD与肾功能损害相关。多变量校正优势比显示，与肝脏正常的受试者相比，NAFLD受试者在有无血糖等协变量校正的情况下发生MKFD的风险明显更高（P = 0.041）。多相互作用分析的进一步结果表明，NAFLD与肾功能受损相关的潜在机制可能是它们具有共同的危险因素和相似的病理过程。结论：本研究最引人注目的发现是，非糖尿病人群中NAFLD与肾功能呈负相关。NAFLD和MKFD可能具有相似的危险因素和/或病理过程。
Background Nonalcoholic fatty liver disease (NAFLD) is associated with the increased burden of kidney. However, there is still no large population study to explore the potential relationship between NAFLD and mild kidney function damage (MKFD) after adjusted for confounding factors. This study is to test the hypothesis that NAFLD is associated with MKFD under controlling the effects of confounding factors. Materials and methods: Levels of serum fasting glucose, creatinine, cholesterol, triglyceride, alanine aminotransferase and aspartate aminotransferase were analyzed from 1412 Chinese Han adults. Questionnaire and physical examination were performed to explore the potential association of NAFLD with kidney function. Results: NAFLD was associated with impairment of kidney function. Multivariate-adjusted odds ratio illustrated that, compared to subjects with normal liver, NAFLD subjects had a significantly higher risk of MKFD with or without adjusted for blood glucose and other covariates (P = 0.041). Further results from multi-interaction analysis demonstrated that the underlying mechanisms linked NAFLD with impaired kidney function may be that they share common risk factors and similar pathological processes. Conclusions: The most striking finding of this study is that NAFLD is negatively associated with kidney function, in nondiabetic population. NAFLD and MKFD may share similar risk factors and/or pathological processes.