STEADY-STATE ANALYSIS AND EVALUATION OF A NEW THERMAL SENSOR FOR SURFACE MEASUREMENTS OF TISSUE PERFUSION
STEADY-STATE ANALYSIS AND EVALUATION OF A NEW THERMAL SENSOR FOR SURFACE MEASUREMENTS OF TISSUE PERFUSION
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DOI：
10.1007/bf02367494
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发表时间：
1983-01-01
影响因子：
3.8
通讯作者：
CASE, RB
中科院分区：
文献类型：
--
作者：
CASTELLANA, FS;SKALAK, R;CASE, RB
对一种用于局部组织灌注表面测量的新型热传感器的稳态响应和工作特性进行了理论分析和体内评价。该流量测量系统采用电隔离薄膜热传感器，通过高频响应电子电路将其保持在固定温度。传感器置于组织表面，测量将固定探头维持在组织温度升高所需的功率，并将其与组织血流相关。采用生物传热方程和基于傅立叶级数的解决方案来描述组织域内的温度分布，进行了稳态探头对流量变化的响应的理论分析。稳态理论的比较，从狗心脏的表面上的初始实验测试，在灌注范围0.51-2.00毫升/分钟每克，得到的结果显示出密切的协议。该探头表现出良好的灵敏度，流量变化，提供稳定和连续的测量，并出现有前途的研究和临床应用。
The steady-state response and operating characteristics of a new thermal sensor for surface measurements of local tissue perfusion were analyzed theoretically and evaluated in vivo. The flow measurement system incorporates an electrically isolated thin-film thermal sensor, which is maintained at a fixed temperature by high frequency response electronic circuitry. The sensor rests on the tissue surface, and the power required to maintain a fixed probe to tissue temperature elevation is measured and related to tissue blood flow. A theoretical analysis of the steady-state probe response to flow changes was carried out employing the bio-heat-transfer equation and a solution based on Fourier series to describe the temperature distribution within the tissue domain. A comparison of steady-state theory to results obtained from initial experimental tests on the surface of the dog heart, over a perfusion range 0.51-2.00 ml/min per g, shows close agreement. The probe demonstrates good sensitivity to flow changes, provides stable and continuous measurements, and appears promising for both research and clinical applications.