Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.1-cm(3)) spatial resolution
Three-dimensional H-1 MR spectroscopic imaging of the in situ human prostate with high (0.24-0.1-cm(3)) spatial resolution
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DOI：
10.1148/radiology.198.3.8628874
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发表时间：
1996-03-01
期刊：
影响因子：
19.7
通讯作者：
Nelson, SJ
中科院分区：
文献类型：
--
作者：
Kurhanewicz, J;Vigneron, DB;Nelson, SJ
目得：评估三维氢-1磁共振波谱成像（3D MRSI）结合临床MR成像检查是否可以根据可观察到的代谢物水平区分前列腺腺癌与正常前列腺区域解剖和良性前列腺增生（BPH）。材料和方法：结合相控阵，直肠MR成像和三维MRSI进行了9名年轻健康志愿者，5例BPH患者，85例前列腺癌和BPH患者。体积MR成像和3D MRSI数据进行了分析校正的直肠内和盆腔相控阵线圈的接收配置文件，对齐的MR成像数据，并与术后病理组织学findings.Results：代谢物水平与前列腺带状解剖，年龄和病理条件的统计学显着变化检测与3D MRSI检查添加到临床MR成像检查。与BPH和正常外周带组织相比，在癌症区域观察到胆碱水平显著较高，柠檬酸盐水平显著较低。癌症区域的比值（胆碱+肌酸/柠檬酸盐）（2.1 +/- 1.3 [标准差]）与正常外周区值无重叠，与BPH值重叠极小（0.61 +/- 0.21）。通过生成代谢物图像来确定前列腺癌的空间范围的估计，其中该代谢物比率显着超过多个连续切片中的正常外周区值。结论：这些结果表明，将3D MRSI检查添加到临床MR成像检查中可能有助于确定前列腺癌的存在和空间范围。
PURPOSE: To evaluate if three-dimensional hydrogen-1 magnetic resonance spectroscopic imaging (3D MRSI) when combined with a clinical MR imaging examination could discriminate prostatic adenocarcinoma from normal prostatic zonal anatomy and benign prostatic hyperplasia (BPH) on the basis of observable metabolite levels.MATERIALS AND METHODS: Combined phased-array, eradorectal MR imaging and 3D MRSI was performed in nine young healthy volunteers, five patients with BPH, and 85 patients with prostate cancer and BPH. Volume MR imaging and 3D MRSI data were analytically corrected for the reception profile of the endorectal and pelvic phased-array coils, aligned with the MR imaging data, and compared with postoperative pathologic histology findings.RESULTS: Statistically significant variations in metabolite levels with prostatic zonal anatomy, age, and pathologic condition were detected with a 3D MRSI examination added to a clinical MR imaging examination. Significantly higher choline levels and significantly lower citrate levels were observed in regions of cancer compared with BPH and normal peripheral zone tissues. The ratio (choline + creatine/citrate) in regions of cancer (2.1 +/- 1.3 [standard deviation]) had no overlap with normal peripheral zone values and minimal overlap with BPH values (0.61 +/- 0.21). An estimate of the spatial extent of prostate cancer was determined by generating metabolite images in which this metabolite ratio significantly exceeded normal peripheral zone values in multiple contiguous sections.CONCLUSION: These results suggest that a 3D MRSI examination added to a clinical MR imaging examination may help define the presence and spatial extent of prostate cancer.