Delivery of genes into the CF airway
Delivery of genes into the CF airway
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DOI：
10.1136/thoraxjnl-2014-205835
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发表时间：
2014-10-01
期刊：
影响因子：
10
通讯作者：
Hyde, Stephen C.
中科院分区：
文献类型：
--
作者：
Gill, Deborah R.;Hyde, Stephen C.
Gene therapy was suggested as a potential treatment for cystic fibrosis (CF), even before the identification of the CFTR gene. Initial enthusiasm has been tempered as it became apparent that reintroduction of the CFTR gene into the cells of the lung is more difficult than anticipated. Here, we review the major gene delivery vectors evaluated clinically, and suggest that advances in either plasmid DNA design and/or hybrid lentivirus biology may finally facilitate lung gene transfer with efficiencies sufficient for CF gene therapy to offer clinical benefit.
