Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species
Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species
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DOI：
10.1016/j.nucmedbio.2003.11.005
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Yanai, K
中科院分区：
文献类型：
--
作者：
Ishiwata, K;Kawamura, K;Yanai, K
[C-11]doxepin已被用作放射配体，用于通过正电子发射断层扫描绘制人脑组胺H-1受体，其特异性结合在五种动物中进行了评估。在小鼠中，用冷多虑平和两种H-1受体拮抗剂治疗可以减少[C-11]多虑平的摄取，但用H-2/H-3拮抗剂治疗则没有。（+）-氯苯那敏（H-1拮抗剂）对小鼠、大鼠、家兔和猴的特异性结合在10-30%范围内，但在豚鼠中未检测到特异性结合。(C) 2004爱思唯尔公司版权所有。
The specific binding of [C-11]doxepin, which has been used as a radioligand for mapping histamine H-1 receptors in human brain by positron emission tomography, was evaluated in five animal species. In mice the [C-11]doxepin uptake was reduced by treatment with cold doxepin and two H-1 receptor antagonists, but not with H-2/H-3 antagonists. The specific binding evaluated with treatment with (+)-chlorpheniramine (H-1 antagonist) was in the range of 10-30% in mouse, rat, rabbit, and monkey, but was not detected in guinea pig. (C) 2004 Elsevier Inc. All rights reserved.