Regulatory mechanisms in the pathways of cartilage and bone formation
Regulatory mechanisms in the pathways of cartilage and bone formation
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DOI：
10.1016/s0955-0674(00)00276-3
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发表时间：
2001-12-01
影响因子：
7.5
通讯作者：
Lefebvre, W
中科院分区：
文献类型：
--
作者：
de Crombrugghe, B;Lefebvre, W
Sox 家族的三个转录因子在软骨细胞分化途径的不同步骤中发挥重要作用。由于成骨细胞分化所需的转录因子 Cbfa1 也会刺激肥大软骨细胞成熟，因此它在软骨内骨形成中将软骨细胞和成骨细胞分化途径联系起来。信号分子，包括 Indian Hedgehog、PTHrP 和 FGF，也在这些途径之间、这些途径的步骤之间或信号分子与转录因子之间建立了重要的联系，因此，软骨内骨形成的更全面的观点正在出现。
Three transcription factors of the Sox family have essential roles in different steps of the chondrocyte differentiation pathway. Because the transcription factor Cbfa1, which is needed for osteoblast differentiation, also stimulates hypertrophic chondrocyte maturation, it links the chondrocyte and osteoblast differentiation pathways in endochondral bone formation. Signaling molecules, including Indian Hedgehog, PTHrP and FGFs, also establish essential links either between these pathways, between steps in these pathways or between signaling molecules and transcription factors, so that a more comprehensive view of endochondral bone formation is emerging.