Sequence-specific 1H, 13C, and 15N backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL
Sequence-specific 1H, 13C, and 15N backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL
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蛋白质酪氨酸磷酸酶 PTP-BL 28 kDa PDZ2/PDZ3 串联结构域的序列特异性 1H、13C 和 15N 主链分配
DOI：
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发表时间：
2007
影响因子：
0.9
通讯作者：
R. Stoll
中科院分区：
文献类型：
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作者：
C. Fetzer;Janelle Sauvageau;Gerd Kock;Carsten Berghaus;J. Bangert;Markus Dicks;R. Heumann;K. S. Erdmann;R. Stoll
蛋白酪氨酸磷酸酶样嗜碱性粒细胞（PTP-BL）是一种含有5个PDZ结构域的大型多结构域非跨膜支架蛋白。本文报道了PTP-BL的PDZ2/PDZ3串联结构域的骨架分配。这些任务现在为PTP-BL的PDZ结构域2和3之间相互作用的详细结构研究提供了基础。这将有助于更好地理解PTB-BL组装的多蛋白复合物中该串联结构域的脚手架功能。
Protein tyrosine phosphatase-basophil like (PTP-BL) represents a large multi domain non-transmembrane scaffolding protein that contains five PDZ domains. Here we report the backbone assignments of the PDZ2/PDZ3 tandem domain of PTP-BL. These assignments now provide a basis for the detailed structural investigation of the interaction between the PDZ domains 2 and 3 of PTP-BL. It will lead to a better understanding of the proposed scaffolding function of this tandem domain in multi-protein complexes assembled by PTB-BL.