Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine
Reinforcement attenuation as a behavioral technique to suppress conditioned avoidance response in rats: A comparative study with olanzapine
复制标题
强化衰减作为抑制大鼠条件性回避反应的行为技术：与奥氮平的比较研究
DOI：
10.1177/0269881118805497
复制
发表时间：
2018-10
影响因子：
4.1
通讯作者：
Ming Li
中科院分区：
文献类型：
--
作者：
Jun Gao;Ming Li
背景资料：抗精神病药物治疗在精神病的治疗中是有效的，尽管它也带来了一些不必要的副作用，并且与低依从性有关。寻找一种非药物替代抗精神病药物治疗是非常可取的。目的：本临床前研究使用条件性回避反应模型检查了这种行为技术的“抗精神病”功效。这种技术，称为强化衰减（RA），是在每次试验结束时给予短暂的足电击（0.1-2.0 s，0.8 mA），无论训练有素的大鼠是否做出回避反应。结果如下：RA达到了与奥氮平（一种非典型抗精神病药物）相同的回避抑制作用，包括在训练有素的Sprague-Dawley成年雄性大鼠中对回避反应的急性抑制和致敏抑制。有趣的是，RA诱导的致敏（回避反应的增强破坏）增强了随后的奥氮平敏感性，而奥氮平（1.0 mg/kg）诱导的致敏对随后的RA治疗几乎没有影响。当RA和奥氮平（0.5 mg/kg，皮下注射）一起使用时，在RA激发试验中仍然可以检测到RA诱导的致敏作用，尽管奥氮平降低了其幅度。最后，我们发现，RA诱导的敏感性回避抑制持续从青春期到成年期，很长一段时间后，这样的治疗被终止。结论：这些结果表明，在青少年和成年动物中，RA在回避抑制作用（急性和致敏作用）方面与抗精神病药物治疗在功能上等同（如果不是上级）。行为疗法，专门针对精神病性思想的爆发者可能是一个可行的战略，为精神病的治疗。
Background: Antipsychotic treatment is effective in the treatment of psychosis, although it also brings with it some unwanted side effects and is associated with low compliance. Finding a non-pharmacological alternative for antipsychotic treatment is highly desirable. Aims: This preclinical study examined the ‘antipsychotic’ efficacy of such a behavioral technique using a conditioned avoidance response model. This technique, termed reinforcement attenuation (RA), is to administer a brief footshock (0.1–2.0 s, 0.8 mA) at the end of each trial regardless of whether a well-trained rat makes an avoidance response or not. Results: RA achieved the same avoidance suppressing effect as olanzapine (an atypical antipsychotic drug), including both acute suppression and sensitized suppression of avoidance response in well-trained Sprague–Dawley adult male rats. Interestingly, the RA-induced sensitization (an enhanced disruption of avoidance responding) enhanced subsequent olanzapine sensitivity, whereas the olanzapine (1.0 mg/kg)-induced sensitization had little impact on later RA treatment. When RA and olanzapine (0.5 mg/kg, subcutaneously) were used together, the RA-induced sensitization was still detectable in the RA challenge test, although its magnitude was reduced by olanzapine. Finally, we showed that the RA-induced sensitization in avoidance suppression persisted from adolescence into adulthood, long after such a treatment was terminated. Conclusions: These findings demonstrate that the RA is functionally equivalent (if not superior) to antipsychotic treatment in the avoidance suppression effect (both acute and sensitization effects) in both adolescent and adult animals. Behavioral therapies that specifically target the reinforcer of psychotic thoughts might be a viable strategy for the treatment of psychosis.
登录
查看更多内容
影响因子：
1.7
作者：
Rathod, Shanaya;Phiri, Peter;Kingdon, David
通讯作者：
Kingdon, David
影响因子：
3.6
作者：
Li, M;Parkes, J;Kapur, S
通讯作者：
Kapur, S
DOI：
10.1016/j.pnpbp.2012.03.007
发表时间：
2012-08-07
影响因子：
5.6
作者：
Zhao, Changjiu;Sun, Tao;Li, Ming
通讯作者：
Li, Ming
DOI：
10.1111/j.1600-0773.1982.tb01032.x
发表时间：
2009-03
期刊：
Acta pharmacologica et toxicologica
影响因子：
--
作者：
J. Arnt
通讯作者：
J. Arnt
DOI：
10.1016/s0140-6736(13)62246-1
发表时间：
2014-04
期刊：
The Lancet
影响因子：
--
作者：
A. Morrison;D. Turkington;M. Pyle;H. Spencer;A. Brabban;G. Dunn;T. Christodoulides;R. Dudley;Nicola H Chapman;P. Callcott;T. Grace;Victoria Lumley;Laura Drage;S. Tully;Kerry Irving;Anna Cummings;R. Byrne;L. Davies;P. Hutton
通讯作者：
A. Morrison;D. Turkington;M. Pyle;H. Spencer;A. Brabban;G. Dunn;T. Christodoulides;R. Dudley;Nicola H Chapman;P. Callcott;T. Grace;Victoria Lumley;Laura Drage;S. Tully;Kerry Irving;Anna Cummings;R. Byrne;L. Davies;P. Hutton