Interaction of stimulus-driven reorienting and expectation in ventral and dorsal frontoparietal and basal ganglia-cortical networks.
Interaction of stimulus-driven reorienting and expectation in ventral and dorsal frontoparietal and basal ganglia-cortical networks.
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DOI：
10.1523/jneurosci.5609-08.2009
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发表时间：
2009-04-08
期刊：
影响因子：
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通讯作者：
Corbetta M
中科院分区：
文献类型：
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作者：
Shulman GL;Astafiev SV;Franke D;Pope DL;Snyder AZ;McAvoy MP;Corbetta M
注意转移到无人值守的刺激（刺激驱动的重定向）通常通过测量对意外刺激的反应来研究，混淆重定向和期望。我们分别测量了这两个因素的血氧水平依赖（BOLD）信号，通过操纵显着的视觉线索，要么转移注意力或保持注意力的视觉刺激流的概率。结果区分三个网络重新定向招募。右颞顶叶交界处（TPJ），腹侧额顶叶网络的后核心，被激活的线索转移比保持注意力独立的线索位置和概率，作为一个开关。TPJ分别调制的低概率线索，这标志着违反空间的期望，独立于他们是否转移注意力。在静息状态下，TPJ活动与右侧额下回（IFG）（腹侧网络的前部组成部分）相关（静息状态功能连接MRI，（rs-fcMRI））。然而，IFG仅在注意力意外转移时被激活，其功能与TPJ无关。基底神经节和额叶/额叶区域也只有在重新定向时才被激活，但它们之间显示出强烈的rs-fcMRI，而不是TPJ/IFG，定义了一个独特的网络，可以检索/激活转移注意力的命令。在背侧额顶叶区域，转移注意力产生持续的空间选择性调制顶内沟（IPS）和FEF，和短暂的选择性调制楔前叶和FEF。即使在可能重新定向时也观察到调制，但在重新定向时意外增加。后者的结果可能部分反映了与基底神经节/额叶/背侧网络的外侧前额叶组件的相互作用，其显示了与背侧网络的显著的rs-fcMRI。
Shifts of attention to unattended stimuli (stimulus-driven reorienting) are often studied by measuring responses to unexpected stimuli, confounding reorienting and expectation. We separately measured the blood-oxygenation-level-dependent (BOLD) signal for both factors by manipulating the probability of salient visual cues that either shifted attention away from or maintained attention on a stream of visual stimuli. The results distinguished three networks recruited by reorienting. Right temporo-parietal junction (TPJ), the posterior core of a ventral fronto-parietal network, was activated more by cues for shifting than maintaining attention independently of cue location and probability, acting as a switch. TPJ was separately modulated by low probability cues, which signaled a breach of spatial expectation, independently of whether they shifted attention. Under resting conditions, TPJ activity was correlated (resting-state functional connectivity MRI, (rs-fcMRI)) with right inferior frontal gyrus (IFG), an anterior component of the ventral network. Nevertheless, IFG was activated only by unexpected shifts of attention, dissociating its function from TPJ. Basal ganglia and frontal/insula regions also were activated only when reorienting was unexpected but showed strong rs-fcMRI among themselves, not with TPJ/IFG, defining a distinct network that may retrieve/activate commands for shifting attention. Within dorsal fronto-parietal regions, shifting attention produced sustained spatially-selective modulations in intraparietal sulcus (IPS) and FEF, and transient less selective modulations in precuneus and FEF. Modulations were observed even when reorienting was likely, but increased when reorienting was unexpected. The latter result may partly reflect interactions with lateral prefrontal components of the basal-ganglia/frontal/insula network that showed significant rs-fcMRI with the dorsal network.