Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): Focus on malignancies
Long-term prognosis of the transient left ventricular dysfunction syndrome (Tako-Tsubo cardiomyopathy): Focus on malignancies
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DOI：
10.1016/j.ejheart.2008.07.008
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发表时间：
2008-10-01
影响因子：
18.2
通讯作者：
Radke, Peter Walter
中科院分区：
文献类型：
--
作者：
Burgdorf, Christof;Kurowski, Volkhard;Radke, Peter Walter
背景资料：短暂性左心室功能不全综合征的病理生理及远期预后（LVDS，Tako-Tsubo心肌病）在很大程度上是未知的。目的：调查恶性肿瘤的患病率和长期死亡率在LVDS患者。方法和结果：50例LVDS患者（47名女性和3名男性，年龄70 - 10岁）和50名年龄和性别匹配的对照组急性前壁心肌梗死（MI）进行了评价。9例LVDS患者（18%）和3例MI患者（6%）在索引事件发生时有恶性肿瘤既往史。随访（2.9 +/- 1.6年）时，LVDS队列中新诊断了7例恶性肿瘤，而对照组中未发现新的恶性肿瘤病例（p=0.01，比值比16.95，95%置信区间[CI] 1.93-304.60）。随访期间两组的总体死亡率没有显著差异（LVDS患者死亡的风险比1.44，95% CI 0.52-3.95，p=0.49）;然而，在死亡患者中，MI患者的心源性死亡更常见（100%对11%的LVDS患者，p < 0.001）。结论：我们的数据表明，LVDS与恶性肿瘤的关联，可能是副肿瘤现象的结果。LVDS患者的长期预后并不比急性MI患者好。(c)2008年欧洲心脏病学会。Elsevier B. V.出版，保留所有权利。
Background: The pathophysiology and long-term prognosis of the transient left ventricular dysfunction syndrome (LVDS, Tako-Tsubo cardiomyopathy) is largely unknown.Aims: To investigate the prevalence of malignancies and long-term mortality in patients with LVDS.Methods and results: Fifty patients with LVDS (47 females and 3 men, age 70 10 years) and 50 age- and gender-matched control patients with acute anterior myocardial infarction (MI) were evaluated. Nine patients (18%) with LVDS and 3 patients (6%) with MI had a previous history of malignancy at the time of the index event. On follow-up (2.9 +/- 1.6 years), 7 malignancies were newly diagnosed in the LVDS cohort whereas no new case of malignancy was found in the control group (p=0.01, odds ratio 16.95, 95% confidence interval [CI] 1.93-304.60). Overall mortality during follow-up did not differ significantly between both groups (hazard ratio 1.44 for death in LVDS patients, 95% CI 0.52-3.95, p=0.49); however, of those patients who died, cardiac deaths were more frequent in patients with MI (100% versus 11% in patients with LVDS, p < 0.001).Conclusions: Our data suggest an association of LVDS with malignancies, potentially as a result of paraneoplastic phenomena. Long-term prognosis of patients with LVDS is no better than in patients with acute MI. (c) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.