Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus.
Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus.
复制标题
大肠杆菌、枯草芽孢杆菌中的信使 RNA 周转过程以及金黄色葡萄球菌的新兴研究。
DOI：
10.1155/2009/525491
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发表时间：
2009
影响因子：
3.4
通讯作者：
Dunman, Paul M
中科院分区：
文献类型：
--
作者：
Anderson, Kelsi L;Dunman, Paul M
mRNA周转的调节是细菌调节基因表达的一种新现象。本文综述了三大类细菌反式作用因子，核糖核酸酶（RNase），RNA结合蛋白，和小的非编码RNA（sRNA），调节转录稳定性和靶基因的蛋白质产生的机制。由于RNA衰变和成熟的机制，最好的特点是在大肠杆菌，大部分的审查将集中在这些因素如何调节mRNA的稳定性，在这个有机体。然而，我们也解决了RNA酶，RNA结合蛋白，sRNA对mRNA的周转，和枯草芽孢杆菌，这已成为研究革兰氏阳性菌的RNA加工的模型中的基因表达的影响。最后，我们讨论了新兴的研究的作用，调节mRNA的稳定性对基因表达的重要人类病原体金黄色葡萄球菌。
The regulation of mRNA turnover is a recently appreciated phenomenon by which bacteria modulate gene expression. This review outlines the mechanisms by which three major classes of bacterial trans-acting factors, ribonucleases (RNases), RNA binding proteins, and small noncoding RNAs (sRNA), regulate the transcript stability and protein production of target genes. Because the mechanisms of RNA decay and maturation are best characterized in Escherichia coli, the majority of this review will focus on how these factors modulate mRNA stability in this organism. However, we also address the effects of RNases, RNA binding proteins, sRNAs on mRNA turnover, and gene expression in Bacillus subtilis, which has served as a model for studying RNA processing in gram-positive organisms. We conclude by discussing emerging studies on the role modulating mRNA stability has on gene expression in the important human pathogen Staphylococcus aureus.