Genetic predisposition to obesity and risk of subclinical atherosclerosis.
Genetic predisposition to obesity and risk of subclinical atherosclerosis.
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DOI：
10.1016/j.gene.2014.07.059
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发表时间：
2014-10
期刊：
影响因子：
3.5
通讯作者：
Juan Shi;Jie Hong;L. Qi;B. Cui;W. Gu;Yifei Zhang;Li-juan Li-Li-juan-Li-2107984010;Lin Miao;Rui Wang;Weiqing Wang;G. Ning
中科院分区：
文献类型：
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作者：
Juan Shi;Jie Hong;L. Qi;B. Cui;W. Gu;Yifei Zhang;Li-juan Li-Li-juan-Li-2107984010;Lin Miao;Rui Wang;Weiqing Wang;G. Ning
肥胖与颈总动脉（CCA）内膜中层厚度（IMT）增加有关，IMT是亚临床动脉粥样硬化的一种指标。我们评估了肥胖遗传易感性与颈动脉IMT之间的关系。该研究包括428名年轻的中国成年人与CCA IMT测量使用高分辨率B型断层超声系统。我们通过总结我们先前分析中证实的6种肥胖相关遗传变异的风险等位基因来创建遗传风险评分（GRS）。校正年龄和性别后，GRS与CCA IMT显著相关（p < 0.001）。GRS每2个等位基因与IMT增加0.023mm相关。通过对肥胖状态的额外调整，这种关联减弱了一半，但仍然具有显著性（p = 0.009）。此外，我们发现血压显著改变了GRS和CCA IMT之间的相关性（相互作用p = 0.001）。收缩压（SBP）≥ 120 mm Hg和/或舒张压（DBP）≥ 80 mm Hg的受试者GRS与CCA IMT之间的相关性更强（GRS每增加2个等位基因，CCA IMT增加0.028 mm，趋势p < 0.001）比SBP < 120 mm Hg和DBP < 80 mm Hg（GRS每增加2个等位基因，CCA IMT减小0.001，趋势p = 0.930）。我们的数据提供了提示性证据，支持肥胖和亚临床动脉粥样硬化之间的潜在因果关系。血压升高可能会放大肥胖对心血管风险的不利影响。
Obesity has been associated with increased common carotid artery (CCA) intima–media thickness (IMT), a measure of subclinical atherosclerosis. We assessed the association between genetic predisposition to obesity and CCA IMT. The study included 428 young Chinese adults with CCA IMT measured using a high-resolution B-mode tomographic ultrasound system. We created a genetic risk score (GRS) by summing the risk alleles of 6 obesity-associated genetic variants confirmed in our previous analyses. The GRS was significantly associated with greater CCA IMT (p < 0.001) after adjustment for age and gender. Per 2 alleles of the GRS was related to 0.023 mm increment in IMT. The association was attenuated by one half with additional adjustment for obesity status, but remained significant (p = 0.009). In addition, we found that blood pressure significantly modified the association between the GRS and CCA IMT (p for interaction = 0.001). The associations between the GRS and CCA IMT were stronger in participants with systolic blood pressure (SBP) ≥ 120 mm Hg and/or diastolic blood pressure (DBP) ≥ 80 mm Hg (per 2 allele increment of the GRS relating to 0.028 mm greater CCA IMT, p for trend < 0.001) than those with SBP < 120 mm Hg and DBP < 80 mm Hg (per 2 allele increment of the GRS relating to 0.001 smaller CCA IMT, p for trend = 0.930). Our data provides suggestive evidence supporting the potential causal relation between obesity and development of subclinical atherosclerosis. Elevated blood pressure might amplify the adverse effect of obesity on cardiovascular risk.