What can imaging reveal about obesity and the brain?
What can imaging reveal about obesity and the brain?
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DOI：
10.2174/156720507780362146
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Jagust, William
中科院分区：
文献类型：
--
作者：
Jagust, William
脑成像在探索衰老和痴呆的脑结构和功能异常方面发挥了重要作用。最近，有报道称肥胖与认知能力下降和痴呆有关，磁共振成像已被用于研究肥胖如何改变大脑结构。这些研究令人信服地证明了全身性和局部性脑萎缩以及白色物质的变化与肥胖有关。这些结果似乎不能简单地用与心血管疾病的联系来解释。然而，这些改变背后的机制尚不清楚，可以通过许多不同的过程来解释，这些过程已知会改变大脑结构，也可能与肥胖有关。应用额外的成像方法可以帮助建立肥胖导致认知能力下降和痴呆的途径。
Brain imaging has played a major role in exploring abnormalities of brain structure and function in aging and dementia. Recently, with reports linking obesity to cognitive decline and dementia, magnetic resonance imaging has been used to investigate how brain structure may be altered with obesity. These studies have convincingly demonstrated both generalized and regional brain atrophy and changes in white matter in association with obesity. These results do not appear to be simply explained by links to cardiovascular disease. However, the mechanisms underlying these alterations are unclear and could be accounted for by a number of different processes that are known to alter brain structure and which could also be related to obesity. Application of additional imaging methods could help to establish the pathway through which obesity produces cognitive decline and dementia.