Systemic markers of inflammation in periodontitis
Systemic markers of inflammation in periodontitis
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DOI：
10.1902/jop.2005.76.11-s.2106
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发表时间：
2005-11-01
影响因子：
4.3
通讯作者：
Loos, BG
中科院分区：
文献类型：
--
作者：
Loos, BG
这篇文献综述总结了目前对牙周炎炎症标记物的系统水平的认识。从外周血样本中讨论了以下细胞因子：白色血细胞、红细胞和血小板的总数。此外，急性时相蛋白，细胞因子和凝血因子的血浆水平进行审查。从现有的文献来看，牙周炎患者的白细胞总数和血浆C反应蛋白水平始终高于健康对照组。牙周炎患者的红细胞数量和血红蛋白水平较低，并有向慢性疾病贫血发展的趋势。在这篇综述中讨论的大多数全身炎症标志物也被认为是心血管疾病的预测标志物。因此，牙周炎中这些标志物的变化可能是流行病学研究中牙周炎与心血管疾病和/或脑血管事件相关的部分解释。据推测，牙周病引起的菌血症的每日发作可能是牙周炎全身标志物变化的原因;在未经治疗的严重患者中，所有牙周病损的累积大小可能达到15至20 cm（2）。
This literature review summarizes current knowledge on the systemic levels of selected markers of inflammation in periodontitis. From samples of peripheral blood the following cellular factors are discussed: total number of white blood cells, red blood cells, and thrombocytes. Further, plasma levels of acute-phase proteins, cytokines, and coagulation factors are reviewed. From the available literature it appears that the total numbers of leukocytes and plasma levels of C-reactive protein are consistently higher in periodontitis patients compared to healthy controls. Numbers of red blood cells and levels of hemoglobin are lower in periodontitis and there is a trend towards anemia of chronic disease. Most systemic markers of inflammation discussed in this review are also regarded as predictive markers for cardiovascular diseases. Therefore, changes in these markers in periodontitis may be part of the explanation why periodontitis is associated with cardiovascular diseases and/or cerebrovascular events in epidemiological studies. It is hypothesized that possibly daily episodes of a bacteremia originating from periodontal lesions are the cause for the changes in systemic markers in periodontitis; the cumulative size of all periodontal lesions in the untreated severe patient may amount to 15 to 20 cm(2).