ROLE OF REOVIRUS TYPE-3 IN PERSISTENT INFANTILE CHOLESTASIS
ROLE OF REOVIRUS TYPE-3 IN PERSISTENT INFANTILE CHOLESTASIS
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DOI：
10.1016/s0022-3476(84)80076-1
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发表时间：
1984-01-01
影响因子：
5.1
通讯作者：
MORECKI, R
中科院分区：
文献类型：
--
作者：
GLASER, JH;BALISTRERI, WF;MORECKI, R
通过测定1岁以下感染和对照婴儿血清中的病毒抗体，研究了呼肠孤病毒3型和持续性婴儿胆汁淤积症之间的关系。婴儿（167）被分为4组：肝外胆道闭锁，特发性新生儿肝炎，或其他胆汁淤积性疾病，和对照组。如果可用，还研究了与婴儿血清同时获得的母体血清。肝外胆道闭锁婴儿（62%）和特发性新生儿肝炎婴儿（52%）具有呼肠孤病毒3型抗体。相反，< 12%的正常婴儿或患有其他胆汁淤积性疾病的婴儿具有抗体。这些观察结果表明，围产期感染呼肠孤病毒3型可能作为一个起始事件的发生2密切相关的形式的婴儿梗阻性胆管病：肝外胆道闭锁和特发性新生儿肝炎。
The relationship between reovirus type 3 and persistent infantile cholestasis was studied by measuring antibody to the virus in the sera of affected and control babies younger than 1 yr of age. Infants (167) were divided into 4 groups: those with extrahepatic biliary atresia, idiopathic neonatal hepatitis, or other cholestatic disorders, and controls. When available, maternal sera obtained simultaneously with infant sera were also studied. Of babies with extrahepatic biliary atresia (62%) and 52% of infants with idiopathic neonatal hepatitis have reovirus 3 antibodies. In contrast, < 12% of either normal infants or babies with other cholestatic disorders have antibodies. These observations suggest that perinatal infection with reovirus type 3 may serve as an initiating event in the genesis of 2 closely related forms of infantile obstructive cholangiopathy: extrahepatic biliary atresia and idiopathic neonatal hepatitis.