THE INFLUENCE OF ALKYL-LYSOPHOSPHOLIPIDS AND LYSOPHOSPHOLIPID-ACTIVATED MACROPHAGES ON THE DEVELOPMENT OF METASTASIS OF 3-LEWIS LUNG-CARCINOMA
THE INFLUENCE OF ALKYL-LYSOPHOSPHOLIPIDS AND LYSOPHOSPHOLIPID-ACTIVATED MACROPHAGES ON THE DEVELOPMENT OF METASTASIS OF 3-LEWIS LUNG-CARCINOMA
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DOI：
10.1016/0014-2964(80)90179-6
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发表时间：
1980-01-01
影响因子：
8.4
通讯作者：
MUNDER, PG
中科院分区：
文献类型：
--
作者：
BERDEL, WE;BAUSERT, WR;MUNDER, PG
烷基溶血磷脂是天然存在的2-溶血磷脂酰胆碱的合成类似物。通过中位生存时间和存活动物数量的增加，证明了它们在C57Bl/6小鼠肺内静脉注射、皮下注射甚至口服均能抑制3-Lewis肺肿瘤的转移发展。静脉注射溶血磷脂活化的骨髓巨噬细胞可增加存活动物数量，延长中位存活时间。
Alkyl-lysophospholipids are synthetic analogs of naturally occurring 2-lysophosphatidylcholine. They inhibit the development of metastasis of 3-Lewis lung tumor in the lung of C57Bl/6 mice if given i.v., i.c. [intracutaneously] or even orally as demonstrated by the increase of the median survival time and the number of surviving animals. I.v. injections of lysophospholipid-activated bone marrow macrophages increase the number of surviving animals and prolong the median survival time.