CYCLIC THROMBOCYTOPENIA INDUCED BY A RICKETTSIA-LIKE AGENT IN DOGS
CYCLIC THROMBOCYTOPENIA INDUCED BY A RICKETTSIA-LIKE AGENT IN DOGS
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DOI：
10.1093/infdis/137.2.182
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发表时间：
1978-01-01
影响因子：
6.4
通讯作者：
GASKIN, JM
中科院分区：
文献类型：
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作者：
HARVEY, JW;SIMPSON, CF;GASKIN, JM
对从[美国]佛罗里达的一只狗中分离的血小板特异性微生物的血液学表现和超微结构进行了研究。通过静脉注射感染的血液，该病原体很容易在实验中传播给成年犬。寄生虫血症和伴随的血小板减少症是周期性的，因为两者都在实验感染后1至2周的相对恒定的时间内复发。出血不是一个疾病的表现，即使血小板减少症是严重的。通过光学和电子显微镜观察微生物。它们仅在血小板中观察到，并且由单个或多个亚基（桑椹胚形式）组成。这些微生物的超微结构与犬埃里希体感染和牛边缘无浆体感染中报道的微生物非常相似。微生物被单膜包围，单膜或多或少地与被双膜包围的亚基的外表面一致。从EM研究，这是建议，这些生物体被归类为目的立克次体。
Hematologic manifestations and the ultrastructure of a platelet-specific microorganism isolated from a dog in Florida [USA] were studied. The agent was readily transmitted experimentally to adult dogs by i.v. inoculation with infected blood. Parasitemias and concomitant thrombocytopenias were cyclic in that both recurred within relatively constant periods of one to two weeks following experimental infections. Hemorrhage was not a manifestation of the disease even though thrombocytopenias were severe. Microorganisms were visualized by light and electron microscopy. They were observed only in platelets and were composed of single or multiple subunits (morula forms). The microorganisms were ultrastructurally very similar to those reported in Ehrlichia canis infections of dogs and Anaplasma marginale infections of cattle. Microorganisms were surrounded by single membranes which more or less conformed to the external surfaces of subunits that were surrounded by double membranes. From EM studies, it is suggested that these organisms be classified in the order Rickettsiales.