Dose-Dependent Risk of Neutropenia after 7-Day Courses of Artesunate Monotherapy in Cambodian Patients with Acute Plasmodium falciparum Malaria
Dose-Dependent Risk of Neutropenia after 7-Day Courses of Artesunate Monotherapy in Cambodian Patients with Acute Plasmodium falciparum Malaria
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DOI：
10.1086/657402
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发表时间：
2010-12-15
影响因子：
11.8
通讯作者：
Fukuda, Mark M.
中科院分区：
文献类型：
--
作者：
Bethell, Delia;Se, Youry;Fukuda, Mark M.
背景。对柬埔寨西部出现的青蒿素耐药性的担忧促使进行了一系列临床试验，研究是否可以通过增加药物剂量来克服对抗疟疾治疗的缓慢反应。给无并发症疟疾患者分配3种口服青蒿琥酯单药治疗方案中的一种（每天2、4或6 mg/kg，连续7天），并观察42天。由于缺乏这些实验剂量的安全性数据，因此实施了一系列安全措施，包括第0、3、6和14天的全血计数。3次给药后，所有组的几何平均绝对中性粒细胞计数均下降，2例患者因中性粒细胞减少(绝对中性粒细胞计数，
Background. Fears of emerging artemisinin resistance in western Cambodia have prompted a series of clinical trials investigating whether slow responses to antimalarial treatment can be overcome by increasing doses of drug.Methods. Patients with uncomplicated malaria were allocated 1 of 3 oral artesunate monotherapy regimens (2, 4, or 6 mg/kg/day for 7 days) and were observed for 42 days. A series of safety measures, including complete blood count on days 0, 3, 6, and 14, was implemented because of a lack of safety data for these experimental doses.Results. After 3 doses, geometric mean absolute neutrophil counts were reduced in all groups, and 2 patients required artesunate to be discontinued because of neutropenia (absolute neutrophil count,