Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial.
Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial.
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DOI：
10.1001/jama.2010.1505
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发表时间：
2010-10-27
期刊：
影响因子：
--
通讯作者：
Jakicic JM
中科院分区：
文献类型：
--
作者：
Goodpaster BH;Delany JP;Otto AD;Kuller L;Vockley J;South-Paul JE;Thomas SB;Brown J;McTigue K;Hames KC;Lang W;Jakicic JM
严重肥胖症的患病率正在显著增加，高血压和2型糖尿病等并存疾病的患病率也在显著增加；然而，除了减肥手术和药物治疗外，很少有临床试验评估严重肥胖症的治疗。目的：确定减肥和体力活动干预对严重肥胖的不良健康风险的有效性。单盲随机试验于2007年2月至2010年4月在匹兹堡大学进行。参与者是从社区招募的130名(37%非裔美国人)严重肥胖(II级或III级)无糖尿病的成年参与者。为期一年的强化生活方式干预，包括饮食和体力活动。其中一组(最初的体力活动)被随机分配到整个12个月的饮食和体力活动；另一组(延迟体力活动)进行相同的饮食干预，但体力活动推迟6个月。重量的变化。次要结果是包括心脏代谢风险的额外成分，包括腰围、腹部脂肪组织和肝脏脂肪含量。在随机抽取的130名参与者中，101名(78%)完成了为期12个月的随访评估。虽然两个干预组在6个月后体重都显著下降，但与延迟活动组相比，初始活动组在前6个月的体重下降更多(10.9公斤[95%可信区间{CI}，9.1-12.7]比8.2公斤[95%可信区间，6.4-9.9]，P=0.02小组×时间互动)。然而，两组在12个月时的体重减轻相似(12.1公斤[95%可信区间，10.0-14.2]比9.9公斤[95%可信区间，8.0-11.7]，P=0.25)。两组患者的腰围、内脏腹脂、肝脂肪含量、血压和胰岛素抵抗均有所降低。体力活动的增加促进了腰围和肝脏脂肪含量的更大幅度的减少。在严重肥胖症患者中，生活方式干预包括饮食和最初或推迟开始的体力活动，导致临床上显著的体重减轻和心脏代谢危险因素的有利变化。
The prevalence of severe obesity is increasing markedly, as is prevalence of comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treatment of severe obesity. To determine the efficacy of a weight loss and physical activity intervention on the adverse health risks of severe obesity. Single-blind randomized trial conducted from February 2007 through April 2010 at the University of Pittsburgh. Participants were 130 (37% African American) severely obese (class II or III) adult participants without diabetes recruited from the community. One-year intensive lifestyle intervention consisting of diet and physical activity. One group (initial physical activity) was randomized to diet and physical activity for the entire 12 months; the other group (delayed physical activity) had the identical dietary intervention but with physical activity delayed for 6 months. Changes in weight. Secondary outcomes were additional components comprising cardiometabolic risk, including waist circumference, abdominal adipose tissue, and hepatic fat content. Of 130 participants randomized, 101 (78%) completed the 12-month follow-up assessments. Although both intervention groups lost a significant amount of weight at 6 months, the initial-activity group lost significantly more weight in the first 6 months compared with the delayed-activity group (10.9 kg [95% confidence interval {CI}, 9.1–12.7] vs 8.2 kg [95% CI, 6.4–9.9], P=.02 for group×time interaction). Weight loss at 12 months, however, was similar in the 2 groups (12.1 kg [95% CI, 10.0–14.2] vs 9.9 kg [95% CI, 8.0–11.7], P=.25 for group×time interaction). Waist circumference, visceral abdominal fat, hepatic fat content, blood pressure, and insulin resistance were all reduced in both groups. The addition of physical activity promoted greater reductions in waist circumference and hepatic fat content. Among patients with severe obesity, a lifestyle intervention involving diet combined with initial or delayed initiation of physical activity resulted in clinically significant weight loss and favorable changes in cardiometabolic risk factors.
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影响因子：
7.1
作者：
Anderson, James W.;Conley, Shannon B.;Nicholas, Amy S.
通讯作者：
Nicholas, Amy S.
影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
9
作者：
FLICKINGER, EG;PORIES, WJ;THOMAS, FT
通讯作者：
THOMAS, FT
影响因子：
4.9
作者：
Paeratakul, S;Lovejoy, JC;Bray, GA
通讯作者：
Bray, GA
DOI：
10.1152/ajpendo.0327.2001
发表时间：
2002-12-01
影响因子：
5.1
作者：
Miyazaki, Y;Glass, L;DeFronzo, RA
通讯作者：
DeFronzo, RA