Haemorrhage produces depressions in alloantigen-specific immune responses in the mouse through activation of suppressor T cells.
Haemorrhage produces depressions in alloantigen-specific immune responses in the mouse through activation of suppressor T cells.
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出血通过激活抑制性 T 细胞，抑制小鼠同种抗原特异性免疫反应。
DOI：
10.1111/j.1365-2249.1990.tb03313.x
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发表时间：
1990
影响因子：
4.6
通讯作者：
Abraham,E
中科院分区：
文献类型：
--
作者：
Chang,YH;Jagels,M;Abraham,E
BALB/c小鼠（H-2d）在失血30%总血量后，针对E14细胞（H-2b）的细胞介导的和体液免疫应答的发展受到抑制（细胞介导的细胞毒性，对照的40-50%;抗体滴度127± 17对对照的287 ±17）。这种出血诱导的免疫应答抑制可以转移到具有来自出血的同基因供体的T细胞（3 × 107）的正常受体。流式显微荧光（FMF）分析显示出血后CD 8：CD 4比值无变化。这些结果表明，出血通过激活抑制性T细胞抑制免疫反应。
The development of cell-mediated and humoral immune responses in BALB/c mice (H-2d) directed toward El4cells (H-2b) was suppressed (cell-mediated cytotoxicity, 40–50% of control; antibody titres 127±17versus287±17 in controls) following haemorrhage of 30% total blood volume. This haemorrhage-induced depression of immune response can be transferred to normal recipients with T cells (3 × 107) from haemorrhaged syngeneic donors. Flow microfluorimetry (FMF) analysis showed no shift in CD8:CD4 ratios following haemorrhage. These results suggest that haemorrhage suppresses immune response through activation of suppressor T cells.