Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin related molecule: Effects on HIV-1 susceptibility
Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin related molecule: Effects on HIV-1 susceptibility
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DOI：
10.1086/499820
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发表时间：
2006-03-01
影响因子：
6.4
通讯作者：
Zhu, TF
中科院分区：
文献类型：
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作者：
Liu, HL;Carrington, M;Zhu, TF
在来自西雅图队列和多中心艾滋病队列研究队列的 1716 名个体中，包括 801 名人类免疫缺陷病毒 (HIV)-1 血清阳性个体、217 名高危 HIV-1 血清阴性个体和 698 名一般 HIV-1 血清阴性个体，研究了 HIV1 易感性与树突状细胞特异性细胞间粘附分子-3-抓取基因重复区多态性之间的关联研究了非整合素相关分子（DC-SIGNR）； DC-SIGNR 重复区域发现了 16 种基因型。 DC-SIGNR 纯合 7/7 重复被发现与 HIV-1 感染风险增加相关（高危 HIV-1 血清阴性个体为 17.5%，HIV-1 血清阳性个体为 28.5%；），而 DC-SIGNR 杂合 7/5 重复 Pp. 0015 往往与 HIV-1 感染抵抗力相关（高危 HIV-1 血清阴性个体中为 35.5%，而 HIV-1 血清阳性个体中为 27.6%；）。这些Pp。 0291 研究结果表明 DC-SIGNR 多态性可能影响 HIV-1 的易感性。
In 1716 individuals-801 human immunodeficiency virus (HIV)-1-seropositive individuals, 217 high-risk HIV-1-seronegative individuals, and 698 general HIV-1-seronegative individuals-from a Seattle cohort and a Multicenter AIDS Cohort Study cohort, the association between HIV1 susceptibility and repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule (DC-SIGNR) was investigated; 16 genotypes were found in the DC-SIGNR repeat region. The DC-SIGNR homozygous 7/7 repeat was found to be associated with an increased risk of HIV-1 infection (17.5% in high-risk HIV-1-seronegative individuals vs. 28.5% in HIV-1-seropositive individuals;), whereas the DC-SIGNR heterozygous 7/5 repeat Pp. 0015 tended to be correlated with resistance to HIV-1 infection (35.5% in high-risk HIV-1-seronegative individuals vs. 27.6% in HIV-1-seropositive individuals;). These Pp. 0291 findings suggest that DC-SIGNR polymorphisms may influence susceptibility to HIV-1.