Nuclear factor-κB1:: Regulation and function
Nuclear factor-κB1:: Regulation and function
复制标题
DOI：
10.1016/j.biocel.2007.05.004
复制
发表时间：
2008-01-01
影响因子：
4
通讯作者：
Oakley, Fiona
中科院分区：
文献类型：
--
作者：
Pereira, Silvia Gaspar;Oakley, Fiona
转录因子nf - κ B是包括细胞存活和炎症在内的许多细胞过程的关键调节因子。NF-kappa B是由NF-kappa B1 （p50及其前体p105）、NF-kappa B2 （p52及其前体p100）、RelA （p65）、RelB和c-Rel等5个NF-kappa B亚基组成的异二聚体或同源二聚体。研究最多的二聚体是p50:p65，它通过经典途径激活，通常促进基因表达。p50和p65的激活与细胞存活和促进炎症有关。本文综述了NF-kappa B亚基的结构、合成和功能；NF-kappa B1 （p105和p50）。讨论了NF-kappa B1与协同激活因子、协同抑制因子和其他影响NF-kappa B1基因表达的信号网络的多种相互作用。最后，将评估NF-kappa B1信号的抗炎作用，并探讨设计利用和增强p50抗炎作用的新型治疗药物的迫切需要。(C) 2007 Elsevier Ltd.版权所有。
The transcription factor NF-kappa B is a critical regulator of many cellular processes including cell survival and inflammation. NF-kappa B functions as a hetero- or homo-dimer which can be formed from five NF-kappa B subunits, NF-kappa B1 (p50 and its precursor p105), NF-kappa B2 (p52 and its precursor p100), RelA (p65), RelB and c-Rel. The most studied dimer is p50:p65, which is activated by the classical pathway and usually promotes gene expression. Activation of p50:p65 is linked with cell survival and promoting inflammation. This review provides a detailed overview of the structure, synthesis and function of the lesser characterised NF-kappa B subunit; NF-kappa B1 (p 105 and p50). The diverse interactions of NF-kappa B1 with co-activators, co-repressors and other signaling networks that influence NF-kappa B1 gene expression are discussed. Finally the anti-inflammatory actions of NF-kappa B1 signaling will be assessed and the crucial need to design novel therapeutic drugs which exploit and amplify the anti-inflammatory actions of p50 will be explored. (C) 2007 Elsevier Ltd. All rights reserved.