Effects of interferon-alpha on human warts.
Effects of interferon-alpha on human warts.
复制标题
干扰素-α对人类疣的影响。
DOI：
10.1089/jir.1982.2.235
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
K. Cantell
中科院分区：
文献类型：
--
作者：
G. Pazin;M. Ho;H. Haverkos;J. Armstrong;M. C. Breinig;H. Wechsler;A. Arvin;T. Merigan;K. Cantell
两名患有广泛疣的患者稳定了两年或两年以上，用人干扰素α治疗，以评估干扰素影响这种病毒病因的良性肿瘤的能力。肌肉注射9660万和1.35亿单位超过12-15周产生软化和减少每个患者的疣的规模。双盲、安慰剂对照的病灶内注射导致干扰素治疗的疣逐渐消失。在8个疣中显示了剂量反应关系。最小有效剂量为15.5周内注射1.2 x 10（6）单位。
Two patients with extensive warts which were stable for two years or more were treated with human interferon-alpha to assess the ability of interferon to affect this benign tumor of viral etiology. Intramuscular administration of 96.6 and 135 million units over 12-15 weeks produced softening and decreased scaling of each patient's warts. Double blind, placebo-controlled intralesional injections resulted in progressive disappearance of interferon treated warts. A dose response relationship was shown in eight warts. The minimum effective dose was 1.2 x 10(6) units injected over 15.5 weeks.