99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: The role of infections in allergy: atopic asthma as a paradigm
99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: The role of infections in allergy: atopic asthma as a paradigm
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DOI：
10.1111/j.1365-2249.2010.04129.x
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发表时间：
2010-04-01
影响因子：
4.6
通讯作者：
van den Biggelaar, A. H. J.
中科院分区：
文献类型：
--
作者：
Holt, P. G.;van den Biggelaar, A. H. J.
“卫生假说”的早期版本，即儿童时期的感染通过刺激辅助性T细胞2型（Th 2）-拮抗性Th 1免疫来预防过敏性疾病，已经逐渐被对潜在细胞和分子相互作用复杂性的更广泛理解所取代。最值得注意的是，现在很清楚，某些类型的微生物暴露，特别是来自正常胃肠道植物群的微生物暴露，可能提供驱动出生后免疫能力发育的关键信号，包括负责对过敏性致敏的天然抗性的机制。其他类型的感染可能会产生匡威的影响，并促进过敏性疾病。我们在下文中回顾了与这一复杂局面的两个方面有关的最新发现。
P>Earlier iterations of the 'hygiene hypothesis', in which infections during childhood protect against allergic disease by stimulation of the T helper type 2 (Th2)-antagonistic Th1 immunity, have been supplanted progressively by a broader understanding of the complexities of the underlying cellular and molecular interactions. Most notably, it is now clear that whole certain types of microbial exposure, in particular from normal gastrointestinal flora, may provide key signals driving postnatal development of immune competence, including mechanisms responsible for natural resistance to allergic sensitization. Other types of infections can exert converse effects and promote allergic disease. We review below recent findings relating to both sides of this complex picture.