Cell death and sexual differentiation of the nervous system
Cell death and sexual differentiation of the nervous system
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DOI：
10.1016/j.neuroscience.2005.07.006
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Forger, NG
中科院分区：
文献类型：
--
作者：
Forger, NG
核体积或神经元数量的性别差异通常归因于细胞死亡的激素控制。在球海绵体肌的脊髓核中，内侧视前核的中央部分和终纹的床核的主核睾丸激素减少围产期的细胞死亡，导致男性在成年期的神经元数量优势。相反，男性在发育过程中有更多的死亡细胞，而在成年期，下丘脑前腹侧室周核的神经元比女性少。这篇综述讨论了性二态性细胞死亡的文献中的一些局限性和未解决的问题，并确定了性腺类固醇可能控制细胞存活的分子机制。特别是，神经营养因子的激素调节和Bcl-2家族蛋白参与神经元数量的性别差异的确定的证据。(C)2005由Elsevier Ltd代表IBRO出版。
Sex differences in nuclear volume or neuron number often are attributed to the hormonal control of cell death. In the spinal nucleus of the bulbocavernosus, the central portion of the medial preoptic nucleus, and the principal nucleus of the bed nucleus of the stria terminalis testicular hormones decrease cell death during perinatal life, resulting in a male advantage in neuron number in adulthood. Conversely, males have more dying cells during development and fewer neurons in adulthood than do females in the anteroventral periventricular nucleus of the hypothalamus. This review discusses several limitations and unresolved issues in the literature on sexually dimorphic cell death, and identifies molecular mechanisms by which gonadal steroids may control cell survival. In particular, evidence is presented for the hormonal regulation of neurotrophic factors and involvement of Bcl-2 family proteins in the determination of sex differences in neuron number. (C) 2005 Published by Elsevier Ltd on behalf of IBRO.