Social position affects bone mass in childhood through opposing actions on height and weight
Social position affects bone mass in childhood through opposing actions on height and weight
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DOI：
10.1359/jbmr.050808
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发表时间：
2005-12-01
影响因子：
6.2
通讯作者：
Tobias, JH
中科院分区：
文献类型：
--
作者：
Clark, EM;Ness, A;Tobias, JH
简介：社会因素影响骨骼生长的证据，提出了可能性，在儿童时期的骨量收购是socialdetermined.Materials和方法：为了澄清社会因素在儿童时期的骨量收购的作用，我们研究了这些变量之间的关系，在雅芳纵向研究的父母和孩子（ALSPAC）。母亲在怀孕期间的社会地位的措施与DXA结果在9.9岁的6702名儿童。调整年龄和性别后进行线性回归分析。由于社会地位可能会影响身高和体重的孩子，分析后，调整这些额外的variables.Results：措施的社会地位，在怀孕期间是无关的全身BMC调整的年龄和性别单独的分析。然而，在调整了与社会地位呈正相关的身高后，BMC与住房保有权（p < 0.001）、母亲教育程度（p <0.001）、父亲教育程度（p <0.001）和社会阶层（p < 0.001）之间存在强烈的负相关。骨面积获得了类似的结果。在调整体重和身高后，社会地位与BMC和骨面积之间的关联不再被观察到。因此，社会地位似乎发挥相反的身高和体重的影响BMC和骨面积在童年。在进一步的分析中，我们发现，调整儿童的脂肪量导致类似的结果与weight.Conclusions：儿童时期的社会地位似乎与儿童时期的骨量获得呈正相关，这是身高增加的结果（即，纵向增长）。然而，这种影响被来自较低社会地位的人增加脂肪沉积以增加骨面积的趋势所抵消，这可能反映了骨生长的刺激。
Introduction: Evidence that social factors influence skeletal growth, raises the possibility that bone mass acquisition in childhood is socially determined.Materials and Methods: To clarify the role of social factors in bone mass acquisition in childhood, we studied relationships between these variables in the Avon Longitudinal Study of Parents and Children (ALSPAC). Measures of the mother's social position during pregnancy were linked to DXA results obtained at age 9.9 years in 6702 children. Linear regression analyses were carried out after adjusting for age and gender. Because social position may affect height and weight of the child, analyses were repeated after adjusting for these additional variables.Results: Measures of social position in pregnancy were unrelated to total body BMC in analyses adjusted for age and gender alone. However, after adjusting for height, which was positively related to social position, a strong negative association was observed between BMC and housing tenure (p < 0.001), maternal education (p < 0.001), paternal education (p < 0.001), and social class (p < 0.001). Similar results were obtained for bone area. After adjusting for weight as well as height, an association between social position and BMC and bone area was no longer observed. Hence, social position seems to exert opposing height- and weight-dependent effects on BMC and bone area in childhood. In further analyses, we found that adjusting for fat mass of the child led to similar results to those obtained with weight.Conclusions: Social position in childhood seems to be positively related to bone mass acquisition in childhood as a consequence of enhanced gain in height (i.e., longitudinal growth). However, this influence is counteracted by the tendency for increased fat deposition in those from a lower social position to increase bone area, presumably reflecting the stimulation of appositional bone growth.