Different degrees of atherosclerosis detected by backscattered ultrasound: An in vitro study on fixed human aortic walls
Different degrees of atherosclerosis detected by backscattered ultrasound: An in vitro study on fixed human aortic walls
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反向散射超声检测不同程度的动脉粥样硬化：固定人主动脉壁的体外研究
DOI：
10.1002/jcu.1870110706
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发表时间：
1983
影响因子：
0.9
通讯作者：
A. L'Abbate
中科院分区：
文献类型：
--
作者：
E. Picano;L. Landini;A. Distante;R. Sarnelli;A. Benassi;A. L'Abbate
本研究的目的是确定超声背向散射信号是否可以表征动脉粥样硬化过程，提供严重程度的定量评估。在离体主动脉标本上进行测量，通过传感器作为发射器和接收器。测量了两种不同的指标，一种是基于峰值幅度值（Vmax），另一种是基于超声反射信号（IBI）的快速傅里叶变换（FFT）分析。200例固定的主动脉壁标本（50例正常，50例脂肪条纹，50例纤维脂肪，50例钙化）首先进行超声表征，然后进行病理学表征，包括肉眼（超声研究前）和组织学（超声研究后）。使用Vmax区分正常、纤维脂肪和钙化标本。脂肪条纹与正常壁重叠，但显着不同的纤维脂肪和钙化子集的值。IBI的结果相似，除了正常和纤维脂肪标本之间的差异无统计学意义。动脉粥样硬化壁声学行为的这种变化可能是由于高回声生物材料的沉积增加，如胶原蛋白、胆固醇晶体（在纤维脂肪标本中）和钙盐（在钙化标本中）。因此，背散射信号似乎提供了指示动脉壁结构由于动脉粥样硬化过程而变化的体外简单参数。
The aim of the study was to establish whether ultrasonic backscattered signals may characterize the atherosclerotic process, providing a quantitative assessment of severity. Measurements on aortic specimens were made in vitro by a transducer acting as transmitter and receiver. Two different indices were measured, one based on peak amplitude value (Vmax) and the other on fast Fourier transform (FFT) analysis of ultrasonic reflected signal (IBI). Two hundred fixed aortic wall specimens (50 normal, 50 fatty streaks, 50 fibrofatty, and 50 calcific) were first characterized ultrasonically and then pathologically, both macroscopically (before ultrasonic study) and histologically (after it). Differentiation of normal, fibrofatty and calcific specimens was achieved using Vmax. Values obtained in fatty streaks overlapped with normal wall but significantly differed from values of fibrofatty and calcific subsets. The results with IBI were similar except that the difference between normal and fibrofatty specimens was not statistically significant. Such changes in acoustic behavior of atherosclerotic walls could be due to increased deposition of highly echogenic biological materials, such as collagen, cholesterol crystals (in fibrofatty specimens), and calcium salts (in calcific ones). Therefore, backscattered signals appear to provide in vitro simple parameters indicative of changes in the arterial wall structure due to the atherosclerotic process.