On the histopathology of liver and liver tumours in thorium-dioxide patients.
On the histopathology of liver and liver tumours in thorium-dioxide patients.
复制标题
关于二氧化钍患者肝脏和肝脏肿瘤的组织病理学。
DOI：
10.1111/j.1699-0463.1972.tb00274.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
H. Poulsen
中科院分区：
文献类型：
--
作者：
J. Visfeldt;H. Poulsen
1966年至1969年进行的5819例尸检中，发现6例肝脏中有Thorotrast沉积物。 1例表现为非特异性反应性肝炎，5例表现为肝硬化。肝硬化为不规则型，4例伴有近期和长期融合性坏死，5例均伴有广泛的被动间隔。根据组织学变化讨论胸透性肝硬化的形态发生。其中四名患者患有很可能由肝脏中的胸腺素沉积物诱发的恶性肿瘤：间皮瘤、血管肉瘤、肝癌和胆管肝癌。血管肉瘤在胸透患者的肝脏中相对频繁地发生，并且在大多数情况下，这些肿瘤含有大的充满血液的空腔。因此，如果已知或怀疑以前曾在血管内应用过托罗曲司特，则禁止在既往未进行血管造影的情况下进行肝活检。在所有 6 例病例中，死亡原因均被认为是托罗曲司特给药的迟发效应。
Among 5819 autopsies carried out over the years 1966 to 1969, 6 cases were found having thorotrast deposits in the liver. One case presented non-specific reactive hepatitis, and 5 cases had cirrhosis. The cirrhoses were of the irregular type, in 4 cases with recent and long-lasting confluent necroses, in all 5 cases with extensive passive septa. The morphogenesis of the thorotrast cirrhosis is discussed on the basis of the histological changes. Four of the patients had malignant tumours which are likely to be induced by thorotrast deposits in the liver: mesothelioma, angiosarcoma, hepatoma and cholangiohepatocarcinoma. Angiosarcomas develop relatively frequently in the liver in thorotrast patients, and in the majority of cases these tumours contain large blood-filled cavities. Consequently, liver biopsy without previous angiography is contra-indicated in cases where former intravasal application of thorotrast is known or suspected. In all 6 cases the cause of death is regarded as late effects of thorotrast administration.