Contact-free spectroscopy of leg ulcers: principle, technique, and calculation of spectroscopic wound scores.
Contact-free spectroscopy of leg ulcers: principle, technique, and calculation of spectroscopic wound scores.
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DOI：
10.1046/j.1523-1747.2001.01297.x
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发表时间：
2001-04
期刊：
影响因子：
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通讯作者：
W. Schmidt;K. Liebold;D. Fassler;U. Wollina
中科院分区：
文献类型：
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作者：
W. Schmidt;K. Liebold;D. Fassler;U. Wollina
客观的伤口监测是循证医学治疗下肢溃疡和其他慢性伤口的重要工具。非侵入性和无接触的光学汇款光谱似乎是一种有用的方法，因为它可以提供更多的信息，相对于传统的伤口评分技术。23名患有慢性静脉、动脉和混合性腿部溃疡的患者参加了这项研究。溃疡的临床状态由临床伤口评分记录（肉芽组织的数量、颜色和稠度）。在可见光和近红外光谱（400-1600 nm）范围内，采用新型二极管阵列光谱仪系统进行光谱读取，分辨率为5 nm。伤口光谱主要取决于血红蛋白和水分的吸收。平均汇款谱与临床伤口评分的最大相关系数不超过+/- 0.5。采用判别分析和聚类分析对伤口评分进行光谱分类。通过交叉验证，预测伤口评分的正确率约为69%。我们的结果表明，光学可见和近红外光谱的应用可以为临床医生提供有价值的治疗方法。
Objective wound monitoring is an essential tool for evidence-based medicine in leg ulcers and other chronic wounds. Non-invasive and contact-free optical remittance spectroscopy seems to be a useful approach as it can provide additional information with respect to more traditional techniques of wound scoring. Twenty-three patients with chronic venous, arterial, and mixed leg ulcers were enrolled in this study. The clinical state of the ulcers was documented by a clinical wound score (quantity, color, and consistency of granulation tissue). The spectroscopic readings were performed with a novel diode-array spectrometer system in the visible and near-infrared range of the spectrum (400-1600 nm) with a resolution of 5 nm. The wound spectra mainly depend on the absorption of hemoglobin and water. The maximum correlation coefficients of mean remittance spectra with the clinical wound scores did not exceed +/- 0.5. Discriminant and cluster analysis were applied for spectral classification of wound scores. By using cross-validation the percentage of correct predicted wound scores was about 69%. Our results indicate that the application of optical visible and near-infrared spectroscopy could be a valuable remedy for the clinician.