Allicin inhibits Pseudomonas aeruginosa virulence by suppressing the rhl and pqs quorum-sensing systems
Allicin inhibits Pseudomonas aeruginosa virulence by suppressing the rhl and pqs quorum-sensing systems
复制标题
大蒜素通过抑制 rhl 和 pqs 群体感应系统来抑制铜绿假单胞菌毒力
DOI：
10.1139/cjm-2019-0055
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发表时间：
2019
影响因子：
2.8
通讯作者：
Zhang Kebin
中科院分区：
文献类型：
--
作者：
Xu Zhimin;Zhang Hong;Yu Hua;Dai Qian;Xiong Junzhi;Sheng Halei;Qiu Jing;Jiang Lu;Peng Jin;He Xiaomei;Xin Rong;Li Defeng;Zhang Kebin
铜绿假单胞菌是一种剧毒细菌，可分泌多种毒力因子，有助于在个体中建立感染。大蒜素源自大蒜，已被证明可以抑制疟原虫毒力因子的产生和生物膜的形成。铜绿假单胞菌。然而，大蒜素介导的 P 调节的机制。铜绿假单胞菌的毒力仍不清楚。在这项研究中，我们研究了大蒜素介导的毒力调节的可能机制。铜绿假单胞菌。结果表明，大蒜素会减弱 P 的产生。通过抑制铜绿藻群体感应系统来抑制铜绿假单胞菌毒力相关因子，例如弹性蛋白酶、绿脓素、pyoverdine 和鼠李糖脂。进一步的分析表明，therhlandpqssystems在大蒜素介导的调控过程中发挥着不同的作用。总而言之，这些结果支持大蒜素作为控制疟原虫的治疗剂的潜在用途。铜绿假单胞菌感染及相关机制。
Pseudomonas aeruginosais a virulent bacterium that secretes a variety of virulence factors that aid in establishing infections in individuals. Allicin, derived from garlic, has been shown to inhibit virulence factor production and biofilm formation inP. aeruginosa. However, the mechanisms underlying the allicin-mediated regulation ofP. aeruginosavirulence remain unclear. In this study, we investigated the possible mechanisms underlying allicin-mediated virulence regulation inP. aeruginosa. The results showed that allicin attenuates the production ofP. aeruginosavirulence-associated factors, such as elastase, pyocyanin, pyoverdine, and rhamnolipids, by inhibiting therhlandpqsquorum-sensing systems. Further analysis revealed that therhlandpqssystems play different roles during the allicin-mediated regulation process. Taken together, these results support the potential use of allicin as a therapeutic agent in controllingP. aeruginosainfection and associated mechanisms.