Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis.
Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis.
复制标题
DOI：
10.1016/j.ymben.2017.02.002
复制
发表时间：
2017-09
影响因子：
8.4
通讯作者：
Stephanopoulos G
中科院分区：
文献类型：
--
作者：
Dong W;Keibler MA;Stephanopoulos G
癌症代谢已成为当代癌症研究不可或缺的一部分。在过去的10年中，稳定同位素示踪剂和网络分析的使用揭示了癌细胞中激活的许多代谢途径。在这里，我们回顾这些途径沿着与特定的示踪剂和标记观察，导致发现他们在癌细胞中重新布线。这些途径包括谷氨酰胺的还原代谢、糖酵解改变、丝氨酸和甘氨酸代谢、突变型异柠檬酸脱氢酶（IDH）诱导的重编程和乙酸代谢的启动。此外，我们证明了同位素标记和网络分析在识别这些途径中的关键作用。本综述中描述的改变并不构成一个完整的列表，未来的研究使用这些强大的工具可能会发现其他癌症相关的途径和癌症治疗的新代谢靶点。
Cancer metabolism has emerged as an indispensable part of contemporary cancer research. During the past 10 years, the use of stable isotopic tracers and network analysis have unveiled a number of metabolic pathways activated in cancer cells. Here, we review such pathways along with the particular tracers and labeling observations that led to the discovery of their rewiring in cancer cells. The list of such pathways comprises the reductive metabolism of glutamine, altered glycolysis, serine and glycine metabolism, mutant isocitrate dehydrogenase (IDH) induced reprogramming and the onset of acetate metabolism. Additionally, we demonstrate the critical role of isotopic labeling and network analysis in identifying these pathways. The alterations described in this review do not constitute a complete list, and future research using these powerful tools is likely to discover other cancer-related pathways and new metabolic targets for cancer therapy.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
9.9
作者：
Gaglio, Daniela;Metallo, Christian M.;Chiaradonna, Ferdinando
通讯作者：
Chiaradonna, Ferdinando
影响因子：
4.1
作者：
Barbosa, MJ;Rocha, JMS;Wijffels, RH
通讯作者：
Wijffels, RH
影响因子：
29
作者：
DeBerardinis RJ
通讯作者：
DeBerardinis RJ
影响因子：
64.8
作者：
Basan M;Hui S;Okano H;Zhang Z;Shen Y;Williamson JR;Hwa T
通讯作者：
Hwa T