Physical Activity Is Associated With Nonalcoholic Fatty Liver Disease and Significant Fibrosis Measured by FibroScan
Physical Activity Is Associated With Nonalcoholic Fatty Liver Disease and Significant Fibrosis Measured by FibroScan
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DOI：
10.1016/j.cgh.2021.06.029
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发表时间：
2022-05-02
影响因子：
12.6
通讯作者：
Ahmed, Aijaz
中科院分区：
文献类型：
--
作者：
Kim, Donghee;Konyn, Peter;Ahmed, Aijaz
背景和目标：需要研究评估2018年美国人体力活动指南（PA指南）与非酒精性脂肪肝（NAFLD）和显著纤维化或肝硬化的关联。我们评估了符合PA指南与NAFLD和显著纤维化或肝硬化的关联，通过美国的瞬时弹性成像方法：使用2017-2018年美国国家健康和营养检查调查数据进行横断面分析。在没有其他慢性肝病原因的情况下，通过瞬时弹性成像确定NAFLD和显著纤维化或肝硬化。详细的PA问卷评估了休闲时间，职业相关，交通相关的PA。结果：在4304名受试者中，符合PA指南（>= 150分钟/周）的休闲时间PA与NAFLD风险降低44%相关（比值比[OR]：0.56; 95%置信区间[CI]：0.46-0.67）。报告1-2倍（150-299分钟/周）或超过2倍（>= 300分钟/周）PA指南推荐量的受试者发生NAFLD的几率分别降低40%（OR，0.60; 95% CI，0.41-0.90）和49%（OR，0.51; 95% CI，0.40-0.65）。当我们同时考虑休闲时间PA和坐着时间时，坐着时间超过8小时的NAFLD风险增加44%（OR，1.44; 95%CI，1.01-2.05）。2倍以上（>= 300分钟/周）的建议量的PA指南休闲时间PA有59%（OR，0.41; 95% CI，0.22-0.74）显著纤维化风险降低，63%（OR，0.37; 95% CI，0.21-0.64）肝硬化的几率较低。满足休闲时间PA的PA指南对NAFLD有有益的影响，超过2倍的PA指南推荐量可降低显著纤维化或肝硬化的风险。
BACKGROUND AND AIMS: Studies evaluating the association of 2018 Physical Activity Guidelines for Americans (PA Guidelines) with nonalcoholic fatty liver disease (NAFLD) and significant fibrosis or cirrhosis are needed. We evaluated the association of meeting PA Guidelines with NAFLD and significant fibrosis or cirrhosis by transient elastography in the United States.METHODS: A cross-sectional analysis was performed using the 2017-2018 U.S. National Health and Nutrition Examination Survey data. NAFLD and significant fibrosis or cirrhosis were defined by transient elastography in the absence of other causes of chronic liver disease. The detailed PA questionnaire assessed the leisure-time, occupation-related, and transportation-related PA. PA was categorized based on the PA Guidelines.RESULTS: Of the 4304 subjects, leisure-time PA, which met the PA Guidelines (>= 150 min/wk), was associated with 44% lower risk of NAFLD (odds ratio [OR]: 0.56; 95% confidence interval [CI]: 0.46-0.67). Subjects who reported 1-2 times (150-299 min/wk) or over 2 times (>= 300 min/wk) the recommended amount of PA Guidelines had 40% (OR, 0.60; 95% CI, 0.41-0.90) and 49% (OR, 0.51; 95% CI, 0.40-0.65) lower odds of NAFLD, respectively. Over 8 hours of sitting time had a 44% higher risk of NAFLD (OR, 1.44; 95% CI, 1.01-2.05) when we considered leisure-time PA and sitting time simultaneously. Over 2 times (>= 300 min/wk) the recommended amount of PA Guidelines for leisure-time PA had 59% (OR, 0.41; 95% CI, 0.22-0.74) lower risk for significant fibrosis and 63% (OR, 0.37; 95% CI, 0.21-0.64) lower odds of cirrhosis.CONCLUSIONS: Meeting PA Guidelines for leisure-time PA has beneficial effects on NAFLD, and over 2 times the recommended amount of PA Guidelines had lower risk for significant fibrosis or cirrhosis.