Working Memory of Patients with Mild Cognitive Impairment due to Brain Trauma Based on fNIRS.
Working Memory of Patients with Mild Cognitive Impairment due to Brain Trauma Based on fNIRS.
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DOI：
10.12116/j.issn.1004-5619.2020.01.011
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发表时间：
2020-02-01
期刊：
影响因子：
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通讯作者：
Cai, W X
中科院分区：
文献类型：
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作者：
Chang, F;Li, H Z;Cai, W X
摘要：目的 探讨脑外伤导致的轻度认知障碍（MCI）人群在执行工作记忆任务时前额叶皮层的激活特征。方法采用心理实验设计软件E-prime，采用N-back范式作为工作记忆任务。采用功能性近红外光谱（fNIRS）检测24名脑外伤所致MCI患者（研究组）和27名性别、年龄相匹配的健康志愿者（对照组）前额叶22个通道的皮质氧合血红蛋白浓度变化。同时记录行为数据，例如击键错误的次数和反应时间。采用独立样本t检验和非参数检验比较两组各任务中氧合血红蛋白浓度变化均值、关键错误数以及反应时间均值。结果（1）两组在1-back和2-back任务中的错误数和反应时间差异有统计学意义（P<0。05）。 2-back任务过程中，两组2、3、7、9、10、11、14、15、18、19、21、22通道氧合血红蛋白浓度变化差异有统计学意义（P
ABSTRACT: Objective To discuss the activation characteristics of the prefrontal cortex of people with mild cognitive impairment （MCI） due to brain trauma during working memory tasks. Methods The psychological experiment design software E-prime was used and N-back paradigm was adopted as working memory task. Functional near-infrared spectroscopy （fNIRS） was used to detect changes in cortical oxygenated hemoglobin concentrations of 22 channels within the prefrontal lobe of 24 people with MCI due to brain trauma （study group） and 27 healthy volunteers （control group） with matching gender and age. Behavioral data, such as the number of keystroke errors and reaction time, were recorded simultaneously. Independent samples t test and non-parametric test were used to compare the mean value of oxygenated hemoglobin concentration change, the number of key errors and the mean value of reaction time of the two groups in each task. Results （1） The differences in the number of errors and reaction time between the two groups in 1-back and 2-back tasks had statistical significance （P0.05）. During the 2-back task, the differences in oxygenated hemoglobin concentration changes of the two groups in channel 2, 3, 7, 9, 10, 11, 14, 15, 18, 19, 21 and 22 had statistical significance （P