Transdermal iontophoresis of 5-fluorouracil combined with electroporation and laser treatment
Transdermal iontophoresis of 5-fluorouracil combined with electroporation and laser treatment
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DOI：
10.1016/j.ijpharm.2003.10.025
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发表时间：
2004-02-11
影响因子：
5.8
通讯作者：
Chan, TF
中科院分区：
文献类型：
--
作者：
Fang, JY;Hung, CF;Chan, TF
研究了离子透入及电穿孔、铒钇铝石榴石（YAG）激光等物理增强方法对5-氟尿嘧啶（5-FU）皮肤透性的影响。离子导入增加了阴离子和非离子形式5-FU的体外透皮转运。结合电穿孔预处理和随后的离子电泳导致5-FU的渗透率高于单独使用任何一种技术。电穿孔处理对角质层（SC）有破坏作用。激光部分烧蚀皮肤SC层，对5-FU的皮肤渗透有很大的增强作用。离子透入的应用进一步增加了药物在激光预处理皮肤上的渗透。在本研究中检测的物理增强方法中，激光一直是增强5-FU输送的最有效技术。(C) 2003 Elsevier B.V.版权所有
The influence of iontophoresis and other physical enhancement methods such as electroporation and erbium:yttrium-aluminum-garnet (YAG) laser on the skin permeation of 5-fluorouracil (5-FU) was examined. Iontophoresis increased the in vitro transdermal transport of both the anionic and non-ionic forms of 5-FU. A combination of electroporation pretreatment and subsequent iontophoresis resulted in a higher permeation of 5-FU than either technique alone. It appeared that electroporation treatment exerted a disruptive influence on the stratum corneum (SC). The SC layers in the skin were partly ablated by the laser, resulting in a great enhancement effect on the skin permeation of 5-FU. Application of iontophoresis further increased the drug permeation across laser-pretreated skin. The laser was consistently the most potent technique to enhance 5-FU delivery among the physical enhancement methods examined in this study. (C) 2003 Elsevier B.V. All rights reserved.