White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study.
White and Gray Matter Volume Changes and Correlation with Visual Evoked Potential in Patients with Optic Neuritis: A Voxel-Based Morphometry Study.
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视神经炎患者白质和灰质体积变化及其与视觉诱发电位的相关性：基于体素的形态测量研究
DOI：
10.12659/msm.897837
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发表时间：
2016-04-05
期刊：
影响因子：
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通讯作者：
Oculopathy fMRI study group
中科院分区：
文献类型：
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作者：
Huang X;Zhang Q;Hu PH;Zhong YL;Zhang Y;Wei R;Xu TT;Shao Y;Oculopathy fMRI study group
本研究的目的是利用基于体素的形态计量学（VBM）研究视神经炎（ON）患者灰质和白色物质的潜在形态学改变及其与行为表现的关系。材料/方法12例ON患者（男4例，女8例）和12例年龄、性别和教育程度相匹配的健康对照者（HC）（男4例，女8例）接受磁共振成像（MRI）检查。采用双样本t检验分析成像数据，以确定灰色和白色物质体积（GMV，WMV）的组间差异。结果ON组与HC组比较，左侧中央后回、左侧额下回、左侧扣带回前、左侧额中回、右侧顶下小叶GMV明显降低;左侧额中回、右侧额上级回、左侧中央前回、右侧顶下小叶WMV降低，左侧梭状回、左侧顶下小叶WMV升高。ON组右眼VEP潜伏期与左侧梭状回WMV信号值呈正相关（r=0.726，p=0.008），与右侧顶下小叶GMV信号值呈负相关（r=-0.611，p=0.035）。ON持续时间与右侧额上上级脑回的WMV信号值呈负相关（r=-0.662，p=0.019），而右眼的最佳矫正视力（VA）与左侧额中脑回的WMV信号值呈负相关（r=-0.704，p=0.011）。结论ON的脑损害可能反映了其病理机制。相关结果表明，ON患者VEP与多个脑区WMV和GMV萎缩密切相关。
Background The aim of this study was to investigate potential morphological alterations of gray and white matter in patients with optic neuritis (ON) and their relationship with behavioral performance, using voxel-based morphometry (VBM). Material/Methods Twelve (4 males, 8 females) patients with ON and 12 (4 males, 8 females) age-, sex-, and education-matched healthy controls (HCs) underwent magnetic resonance imaging (MRI). Imaging data were analyzed using two-sample t tests to identify group differences in gray and white matter volume (GMV, WMV). Correlation analysis was used to explore relationships between observed GMV and WMV of different areas and visual evoked potential (VEP) in ON. Results Compared with HCs, ON patients had: significantly decreased GMV in the left postcentral gyrus, left inferior frontal gyrus, left anterior cingulate, left and right middle frontal gyrus, and right inferior parietal lobule; decreased WMV in the left middle frontal gyrus, right superior frontal gyrus, left precentral gyrus and right inferior parietal lobule; and increased WMV in the left fusiform gyrus and left inferior parietal lobule. VEP latency of the right eye in ON correlated positively with WMV signal value of the left fusiform gyrus (r=0.726, p=0.008), and negatively with GMV signal value of the right inferior parietal lobule (r=−0.611, p=0.035). Duration of ON correlated negatively with WMV signal value of the right superior frontal gyrus (r=−0.662, p=0.019), while best-corrected visual acuity (VA) of the right eye correlated negatively with WMV signal value of the left middle frontal gyrus (r=−0.704, p=0.011). Conclusions These results suggest significant brain involvement in ON, which may reflect the underlying pathologic mechanism. Correlational results demonstrate that VEP in ON is closely associated with WMV and GMV atrophy in many brain regions.
DOI：
10.12659/msm.883473
发表时间：
2012-10
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
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作者：
Langwińska-Wośko E;Szulborski K;Broniek-Kowalik K
通讯作者：
Broniek-Kowalik K