HER3 Overexpression as an Independent Indicator of Poor Prognosis for Patients with Curatively Resected Pancreatic Cancer
HER3 Overexpression as an Independent Indicator of Poor Prognosis for Patients with Curatively Resected Pancreatic Cancer
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DOI：
10.1159/000333825
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发表时间：
2011-01-01
期刊：
影响因子：
3.5
通讯作者：
Hirakawa, Kosei
中科院分区：
文献类型：
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作者：
Hirakawa, Toshiki;Nakata, Bunzo;Hirakawa, Kosei
目的：研究了人表皮生长因子受体3（HER 3）过表达与胰腺癌根治性切除患者生存率之间的关系。研究方法：从126例胰腺癌组织标本无血行或腹膜转移恢复宏观根治性切除术用福尔马林固定，石蜡包埋和免疫组化染色。基于染色强度，将半定量评分0（无染色或少于10%的癌细胞染色）、1+、2+或3+分配给每个样品。评分2+或3+定义为HER 3阳性染色，即。例如，HER 3过表达。结果：在126例组织样本中，52例（41.3%）观察到HER 3过表达。HER 3过表达与临床病理因素，包括肿瘤位置、肿瘤大小、肿瘤分化程度、国际抗癌联合会的T/N分类和血清碳水化合物抗体19-9水平（CA 19 -9）之间无相关性。单变量分析显示，HER 3过表达患者的中位生存时间为37.2个月，而HER 3阴性样本患者的中位生存时间为58.6个月（p = 0.008）。多因素生存分析显示，HER 3过表达、淋巴结转移和血清CA 19 -9水平升高是预后不良的独立预测因素。结论：HER 3过表达是胰腺癌术后一个新的预后预测因子。版权所有（C）2011 S. Karger AG，巴塞尔
Objective: The association between human epidermal growth factor receptor 3 (HER3) overexpression and survival in patients with curatively resected pancreatic cancer was investigated. Methods: Tissue samples from 126 pancreatic cancers without hematogenous or peritoneal metastases recovered from macroscopically curative resection were fixed with formalin, embedded in paraffin and subjected to immunohistochemical staining. Semiquantitative scores of zero (no staining or staining in less than 10% of cancer cells), 1+, 2+, or 3+ were assigned to each sample based on the intensity of staining. Scores of 2+ or 3+ were defined as HER3-positive staining, i. e., HER3 overexpression. Results: HER3 overexpression was observed in 52 of the 126 tissue samples (41.3%). There were no associations between HER3 overexpression and clinicopathological factors, including tumor location, tumor size, tumor differentiation, T/N categories according to the International Union against Cancer, and serum carbohydrate antibody 19-9 level (CA19-9). Univariate analysis demonstrated the median survival time of patients with HER3 overexpression was 37.2 months, while that of patients with HER3-negative samples was 58.6 months (p = 0.008). HER3 overexpression, lymph node metastasis, and elevated serum CA19-9 level were independent predictors of poor prognosis based on multivariate survival analysis. Conclusion: A new prognostic predictor, HER3 overexpression, was identified for resected pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel