Regional Differences in Grey and White Matter in Children and Adults With Autism Spectrum Disorders: An Activation Likelihood Estimate (ALE) Meta-analysis
Regional Differences in Grey and White Matter in Children and Adults With Autism Spectrum Disorders: An Activation Likelihood Estimate (ALE) Meta-analysis
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DOI：
10.1002/aur.235
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发表时间：
2012-02-01
期刊：
影响因子：
4.7
通讯作者：
Roberts, S. Wendy
中科院分区：
文献类型：
--
作者：
Duerden, Emma G.;Mak-Fan, Kathleen M.;Roberts, S. Wendy
与患有自闭症谱系障碍（ASD）的成人相比，儿童脑形态结构改变的报道并不一致。我们通过对19项基于体素的形态测量学研究的数据进行荟萃分析来评估这些差异。各年龄组的共同发现是左壳核和内侧前额叶皮质（mPFC）的灰质减少和外侧PFC的灰质增加，而白色物质减少主要见于额纹状体通路的儿童。在ASD样本中，儿童/青少年比成年人更可能在双侧梭状回、右侧扣带回和小脑中有灰质增加。结果表明，只有儿童/青少年的社会认知和边缘处理区域存在明显的成熟差异，而ASD成年人则没有，这可能是该人群随着年龄增长而改善的情绪调节的基础。Autism Res 2012，5：49-66. (c)2011年国际自闭症研究学会，Wiley Periodicals，Inc。
Structural alterations in brain morphology have been inconsistently reported in children compared to adults with autism spectrum disorder (ASD). We assessed these differences by performing meta-analysis on the data from 19 voxel-based morphometry studies. Common findings across the age groups were grey matter reduction in left putamen and medial prefrontal cortex (mPFC) and grey matter increases in the lateral PFC, while white matter decreases were seen mainly in the children in frontostriatal pathways. In the ASD sample, children/adolescents were more likely than adults to have increased grey matter in bilateral fusiform gyrus, right cingulate and insula. Results show that clear maturational differences exist in social cognition and limbic processing regions only in children/adolescents and not in adults with ASD, and may underlie the emotional regulation that improves with age in this population. Autism Res 2012,5:49-66. (c) 2011 International Society for Autism Research, Wiley Periodicals, Inc.