X-marks the spot: X-chromosome identification during dosage compensation.
X-marks the spot: X-chromosome identification during dosage compensation.
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DOI：
10.1016/j.bbagrm.2013.12.007
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Larschan E
中科院分区：
文献类型：
--
作者：
Chery J;Larschan E
剂量补偿是在异性配子物种中使X连锁基因在两性间的剂量相等的基本过程。因为沿着单个染色体长度的所有基因都是共同调节的，所以剂量补偿作为一个模型系统来理解协调基因调节域是如何建立的。剂量补偿在哺乳动物、苍蝇和蠕虫中研究得最好。尽管剂量补偿系统似乎在不同物种之间存在差异，但有一些关键的共同成核和传播原理对于将剂量补偿复合体准确靶向X染色体至关重要(S)。我们将强调长的非编码RNA与DNA序列元件一起作用于X染色体的机制。这篇文章是题为：染色质和动物发育的表观遗传调控的特刊的一部分。
Dosage compensation is the essential process that equalizes the dosage of X-linked genes between the sexes in heterogametic species. Because all of the genes along the length of a single chromosome are co-regulated, dosage compensation serves as a model system for understanding how domains of coordinate gene regulation are established. Dosage compensation has been best studied in mammals, flies and worms. Although dosage compensation systems are seemingly diverse across species, there are key shared principles of nucleation and spreading that are critical for accurate targeting of the dosage compensation complex to the X-chromosome(s). We will highlight the mechanisms by which long non-coding RNAs function together with DNA sequence elements to tether dosage compensation complexes to the X-chromosome. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
影响因子：
3.7
作者：
Lusk RW;Eisen MB
通讯作者：
Eisen MB