Higher malnutrition risk is related to increased intramuscular adipose tissue of the quadriceps in older inpatients: A cross-sectional study
Higher malnutrition risk is related to increased intramuscular adipose tissue of the quadriceps in older inpatients: A cross-sectional study
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DOI：
10.1016/j.clnu.2019.11.028
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发表时间：
2020-08-01
影响因子：
6.3
通讯作者：
Moriyama, Hideki
中科院分区：
文献类型：
--
作者：
Akazawa, Naoki;Okawa, Naomi;Moriyama, Hideki
背景和目标：尽管在老年住院患者中观察到营养不良风险率很高，但营养不良风险与股四头肌肌内脂肪组织之间的关系仍不清楚。了解这种关系将是必要的老年住院病人的管理计划。本研究旨在探讨老年住院患者股四头肌肌内脂肪组织与营养不良风险之间的关系。使用老年营养风险指数（GNRI）评估营养不良风险。根据超声回波强度评估股四头肌的肌内脂肪组织。回声强度越高表明肌内脂肪组织的量越多。采用多元回归分析确定与股四头肌回声强度独立相关的因素。GNRI、年龄、性别将患者（男1例，女2例）、用药次数、C反应蛋白、更新的Charlson合并症指数、食物摄入水平量表、大腿皮下脂肪厚度、运动功能独立性指标和住院时间设为自变量。GNRI（β = -0.18），年龄（β = 0.18），性别（β = 0.22），用药次数（beta = 0.09），大腿皮下脂肪厚度（β = -0.29），电动机制动器（β = -0.12）和住院时间（β = 0.11）与股四头肌回声强度显著且独立相关。目前的结果显示，即使在调整了其他特征后，老年住院患者的股四头肌肌内脂肪组织增加也与营养不良风险较高有关。营养干预可能是必要的，以减少肌内脂肪组织的老年住院病人有较高的营养不良的风险。(C)2019年爱思唯尔有限公司和欧洲临床营养与代谢学会。All rights reserved.
Background & aims: The relationship between malnutrition risk and intramuscular adipose tissue of the quadriceps in older inpatients remains unclear, although a high rate of malnutrition risk has been observed in these patients. Understanding this relationship would be necessary for a management plans for older inpatients. This study aimed to examine the relationship between malnutrition risk and intramuscular adipose tissue of the quadriceps in older inpatients.Methods: Three-hundred and twenty-three older inpatients participated in this cross-sectional study. Malnutrition risk was assessed using the Geriatric Nutritional Risk Index (GNRI). Intramuscular adipose tissue of the quadriceps was assessed based on ultrasound echo intensity. Higher echo-intensity indicates greater amounts of intramuscular adipose tissue. Multiple regression analysis was used to identify the factors that were independently associated with quadriceps echo intensity. GNRI, age, sex (male = 1, female = 2), number of medications, C-reactive protein, updated Charlson comorbidity index, Food Intake Level Scale, the subcutaneous fat thickness of the thigh, motor-Functional Independence Measures, and length of hospital stay were set as the independent variables.Results: GNRI (beta = -0.18), age (beta = 0.18), sex (beta = 0.22), number of medications (beta = 0.09), the subcutaneous fat thickness of the thigh (beta = -0.29), motor-FIM (beta = -0.12), and length of hospital stay (beta = 0.11) were significantly and independently associated with the quadriceps echo intensity.Conclusions: The current results revealed that higher malnutrition risk was associated with increased intramuscular adipose tissue of the quadriceps of older inpatients even after adjusting for other characteristics. Nutritional intervention may be necessary for decreasing intramuscular adipose tissue of the quadriceps in older inpatients who have higher malnutrition risk. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.